Sustained release of sulfamethizole from agar beads after oral administration to humans

Autor:	Yuhko Nakamura, Masahiro Nakano, Masahiko Kouketsu, Kazuhiko Juni
Rok vydání:	1980
Předmět:	Sulfathiazoles food.ingredient Chromatography Chemistry Sulfamethizole General Chemistry General Medicine Urine Pharmacology Sustained release dosage forms Dosage form Excretion Agar food In vivo Oral administration Delayed-Action Preparations Drug Discovery medicine Humans medicine.drug
Zdroj:	Chemicalpharmaceutical bulletin. 28(10)
ISSN:	0009-2363
Popis:	The use of agar beads for sustained release of a urinary tract disinfectant was examined in vivo. Agar beads containing dispersed sulfamethizole were administered to five healthy volunteers, and the rate of excretion of the drug in urine was determined for pharmacokinetic analysis. The results indicated that agar beads should be useful for the preparation of sustained release dosage forms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9aadf5af67e84203a9bc9b44b534f79 https://pubmed.ncbi.nlm.nih.gov/7448939 Zobrazit plný text záznamu