Toll-like receptors in systemic lupus erythematosus: potential targets for therapeutic intervention
| Autor: | Christopher G. Horton, A. Darise Farris |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Pulmonary and Respiratory Medicine
Systemic lupus erythematosus Lupus erythematosus business.industry Immunology Toll-Like Receptors Autoimmunity DNA medicine.disease medicine.disease_cause Article DNA metabolism Intervention (counseling) Nucleic Acids medicine Immunology and Allergy Animals Humans Lupus Erythematosus Systemic Receptor business Immunosuppressive Agents |
| Zdroj: | Current allergy and asthma reports. 12(1) |
| ISSN: | 1534-6315 |
| Popis: | Toll-like receptors have attracted increased attention in recent years, not only for their role in sensing conserved microbial components, but also in the realm of autoimmunity. Though TLRs are most widely known for their capacity to detect conserved motifs of infectious agents, mounting evidence indicates that these innate receptors also promote autoimmune conditions by causing uncontrolled auto-inflammation as a result of chronic recognition of self. In response to the need for modern approaches for treatment of autoimmune diseases, several groups have begun investigating ways to target TLRs as new therapeutic options for autoimmune conditions. Here we discuss recent data describing advancements in Toll-like receptors as therapeutic targets for treatment of autoimmune diseases, with a focus on systemic lupus erythematosus. |
| Databáze: | OpenAIRE |
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