High resolution three-dimensional brain atlas using an average magnetic resonance image of 40 adult C57Bl/6J mice
| Autor: | R. M. Henkelman, Adrienne Dorr, Noor Jehan Kabani, Shoshana Spring, Jason P. Lerch |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Models Anatomic Computer science Cognitive Neuroscience Models Neurological Mice Imaging Three-Dimensional Atlas (anatomy) medicine Animals Computer Simulation medicine.diagnostic_test business.industry Brain atlas Brain Magnetic resonance imaging Anatomy Image Enhancement Magnetic Resonance Imaging Sagittal plane Mice Inbred C57BL Skull medicine.anatomical_structure Neurology Coronal plane Female Nuclear medicine business Neuroanatomy |
| Zdroj: | NeuroImage. 42:60-69 |
| ISSN: | 1053-8119 |
| Popis: | Detailed anatomical atlases can provide considerable interpretive power in studies of both human and rodent neuroanatomy. Here we describe a three-dimensional atlas of the mouse brain, manually segmented into 62 structures, based on an average of 32 mum isotropic resolution T(2)-weighted, within skull images of forty 12 week old C57Bl/6J mice, scanned on a 7 T scanner. Individual scans were normalized, registered, and averaged into one volume. Structures within the cerebrum, cerebellum, and brainstem were painted on each slice of the average MR image while using simultaneous viewing of the coronal, sagittal and horizontal orientations. The final product, which will be freely available to the research community, provides the most detailed MR-based, three-dimensional neuroanatomical atlas of the whole brain yet created. The atlas is furthermore accompanied by ancillary detailed descriptions of boundaries for each structure and provides high quality neuroanatomical details pertinent to MR studies using mouse models in research. |
| Databáze: | OpenAIRE |
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