Synthesis, Structural Characterization, and Biological Evaluation of Oxorhenium(V) Complexes with a Novel Type of Thiosemicarbazones Derived from N-[N′,N′-Dialkylamino(thiocarbonyl)]benzimidoyl Chlorides
| Autor: | Ronald Gust, Silke Bergemann, Victor M. Deflon, Hung Huy Nguyen, Pedro I. S. Maia, Jesudas J. Jegathesh, Ulrich Abram |
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| Rok vydání: | 2009 |
| Předmět: |
Thiosemicarbazones
Stereochemistry Microbial Sensitivity Tests Ligands Chloride Inorganic Chemistry Metal Structure-Activity Relationship chemistry.chemical_compound Chlorides Cell Line Tumor medicine Humans Physical and Theoretical Chemistry Cytotoxicity Semicarbazone Alkyl Biological evaluation chemistry.chemical_classification Molecular Structure Ligand Biological activity Organotechnetium Compounds Rhenium chemistry visual_art visual_art.visual_art_medium Drug Screening Assays Antitumor medicine.drug |
| Zdroj: | Inorganic Chemistry. 48:9356-9364 |
| ISSN: | 1520-510X 0020-1669 |
| Popis: | Reactions of N-[N',N'-diethylamino(thiocarbonyl)]benzimidoyl chloride with 4,4-dialkylthiosemicarbazides give a novel class of thiosemicarbazides/thiosemicarbazones, H(2)L, which causes a remarkable reduction of cell growth in in vitro experiments. These strong antiproliferative effects are also observed for oxorhenium(V) complexes of the general composition [ReOCl(L)], which are formed by reactions of the potentially tridentate ligands with (NBu(4))[ReOCl(4)]. A systematic substitution of the alkyl groups in the thiosemicarbazone building blocks of the ligands do not significantly influence the biological activity of the metal complexes, while the replacement of the chloro ligand by a PPh(3) ligand (by the replacement of the oxo unit by a nitrido ligand) completely terminated the cytotoxicity of the metal complexes. |
| Databáze: | OpenAIRE |
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