Mitotic spindle orientation: JAM-A can fix it

Autor: Hüseyin Tuncay, Benjamin F. Brinkmann, Klaus Ebnet
Rok vydání: 2015
Předmět:
Zdroj: Cell Cycle. 14:3773-3774
ISSN: 1551-4005
1538-4101
DOI: 10.1080/15384101.2015.1105696
Popis: Epithelial cells form sheets of cells which are connected by intercellular junctions. When epithelial cells divide the mitotic spindle is aligned in the plane of the sheet, which ensures that both daughter cells are retained in the sheet. The planar orientation of the spindle apparatus must be a tightly regulated process as randomized spindle orientation would result in the delamination of cells and eventually in their transformation and metastasis.
Databáze: OpenAIRE