High Prevalence of Self-Reported Exposure to Adulterated Drugs Among People Who Experienced an Opioid Overdose in Canada: A Cohort Study

Autor:	Christopher Fairgrieve, M.-J. Milloy, Ekaterina Nosova, Amy Prangnell, Kora DeBeck, Kanna Hayashi
Rok vydání:	2019
Předmět:	Adult Male medicine.medical_specialty Canada Health (social science) Prevalence 030508 substance abuse Medicine (miscellaneous) Article Heroin Cohort Studies 03 medical and health sciences Young Adult 0302 clinical medicine Risk Factors Environmental health mental disorders Epidemiology medicine Humans 030212 general & internal medicine Prospective Studies High prevalence business.industry Public Health Environmental and Occupational Health Opioid overdose Middle Aged medicine.disease 3. Good health Substance abuse Analgesics Opioid Psychiatry and Mental health Female Self Report Drug Overdose 0305 other medical science Risk assessment business Drug Contamination medicine.drug Cohort study
Zdroj:	Substance usemisuse. 54(6)
ISSN:	1532-2491
Popis:	BACKGROUND: In North America, rates of overdoses are increasing largely due to the adulteration of illicit drugs by illicit synthetic opioids. OBJECTIVES: We sought to examine the prevalence and correlates of self-reported exposure to adulterated drugs among people who experienced a non-fatal opioid overdose. METHODS: Data were derived from three prospective cohort studies of people who use drugs in Vancouver, Canada between June and November 2016. Multivariable logistic regression analyses were used to examine the prevalence and correlates of self-reported exposure to adulterated drugs. RESULTS: Among 117 participants who reported symptoms consistent with a non-fatal opioid overdose, 78 (66.7%) reported believing the drug was adulterated during their last overdose. Of those, 42 (53.8%) had not perceived adulteration prior to overdose. In the multivariable analysis, engagement in opioid agonist therapy (Adjusted Odds Ratio [AOR] = 2.79, 95% Confidence Interval [CI]: 1.10, 7.45) was independently associated with having not perceived adulteration prior to overdose. Daily heroin use (AOR = 5.28; 95% CI: 1.92, 15.97) and reporting supervised injection site staff were present at most recent overdose (AOR = 6.16; 95% CI: 1.25, 47.27) were independently associated with having perceived adulteration prior to overdose. CONCLUSIONS/IMPORTANCE: We found a high prevalence of believing adulterated drugs were present for the most recent overdose. Further, the high prevalence of unperceived adulteration prior to overdose supports the need to lower the risk of overdose by providing individuals with options to consume drugs in a safer manner, including supervised consumption sites.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97ff154ffb6b075bda269a2a24347cf https://pubmed.ncbi.nlm.nih.gov/30663484 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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