Thiol–Chromene 'Click' Reaction Triggered Self-Immolative for NIR Visualization of Thiol Flux in Physiology and Pathology of Living Cells and Mice
| Autor: | Tingting Zhou, Wei Li, Ming Jin, Keyan Zhou, Dandan Liu, Caixia Yin, Xue Li, Fangjun Huo, Yutao Yang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
010402 general chemistry
01 natural sciences Biochemistry Catalysis Mice Colloid and Surface Chemistry Molecular level Cell Line Tumor Animals Humans Benzopyrans Sulfhydryl Compounds Fluorescent Dyes chemistry.chemical_classification Mice Inbred BALB C Spectroscopy Near-Infrared Optical Imaging fungi food and beverages General Chemistry 0104 chemical sciences Oxidative Stress chemistry Thiol Biophysics Click chemistry Click Chemistry Flux (metabolism) |
| Zdroj: | Journal of the American Chemical Society. 142:1614-1620 |
| ISSN: | 1520-5126 0002-7863 |
| Popis: | Understanding the pathological process of biological systems can greatly improve the prevention and treatment of diseases. The study of pathological processes has now reached the molecular level, and molecular fluorescent probes have become a powerful tool. Chromene, also known as benzo-pyran molecule, is a structural element of natural products with good biological compatibility and was developed as a fluorescent probe. The thiol-chromene "click" nucleophilic pyran ring-opening reaction allows the quick detection of thiol. In this work, the chromene alcohol can function as an efficient self-immolative spacer, which covalently links NIR fluorophore via a carbonyl ester. Due to its favorable characteristics and superior applicability, the self-immolative amplifier |
| Databáze: | OpenAIRE |
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