Waist circumference is a major determinant of oxidative stress in subjects with and without metabolic syndrome

Autor: Mini Sara Abraham, Hema Unnikannan, Samir Awadallah, Amita Attlee, Veena Raigangar, Hayder Hasan, Latifa M. Rashid, Mohamed Madkour
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
Endocrinology
Diabetes and Metabolism
Blood Pressure
medicine.disease_cause
Antioxidants
Body Mass Index
chemistry.chemical_compound
0302 clinical medicine
Malondialdehyde
Metabolic Syndrome
chemistry.chemical_classification
medicine.diagnostic_test
Incidence
Glutathione peroxidase
General Medicine
Middle Aged
Prognosis
Female
Waist Circumference
Adult
medicine.medical_specialty
Waist
United Arab Emirates
030209 endocrinology & metabolism
Young Adult
03 medical and health sciences
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Humans
Glutathione Peroxidase
030109 nutrition & dietetics
Superoxide Dismutase
business.industry
Glutathione
medicine.disease
Oxidative Stress
Cross-Sectional Studies
Endocrinology
chemistry
Case-Control Studies
Metabolic syndrome
Lipid profile
business
Biomarkers
Oxidative stress
Follow-Up Studies
Zdroj: Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 13:2541-2547
ISSN: 1871-4021
Popis: Aim Oxidative stress (OS) plays a major role in pathogenic mechanisms associated with metabolic syndrome (Mets) yet the main component of Mets contributing most to OS is not well elucidated. Hence, the aim of this study was to investigate the oxidative-antioxidative status in Mets subjects and to determine the main predicting component of OS. Methods Anthropometric measures, fasting blood glucose, lipid profile, antioxidant enzymes [catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPx)], reduced glutathione (GSH), malondialdehyde (MDA) and protein carbonyl were assessed in 172 adult UAE residents. International Diabetes Federation criteria were used for Mets diagnosis. Mets Scores (0–5) were calculated and assigned per subject based on number of components. Results Of all participants, 22.1% had Mets and 49.4% had large waist circumference (WC). Significant lower levels of catalase, SOD, GPx and GSH, and higher levels of MDA and protein carbonyl were observed in subjects with Mets. In addition, catalase, SOD, GPx, and GSH correlated negatively, while MDA and protein carbonyl correlated positively with almost all Mets components. Similar trend of correlations was noticed with Mets Scores. When adjusted for age and gender, linear regression analysis revealed that subjects with large WC demonstrated significantly lower levels of antioxidative enzymes and GSH, and higher levels of MDA and protein carbonyl. Consequently, WC emerged as the best predictor of OS. Conclusions The degree of OS is dependent on the Mets Scores, and WC contributes independently to increased OS among adults in UAE.
Databáze: OpenAIRE
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