Adult-onset Still's disease with macrophage activation syndrome successfully treated with a combination of methotrexate and etanercept
| Autor: | Itomi Abe, Keisuke Maeshima, Misuzu Akamine, Hajime Hamasaki, Miwa Haranaka, Koji Ishii, Hironobu Yoshimatsu, Hiroshi Tatsukawa, Mikako Iwakura |
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| Rok vydání: | 2011 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Adult-onset Still's disease Combination therapy Adolescent Disease Gastroenterology Receptors Tumor Necrosis Factor Etanercept Rheumatology immune system diseases Internal medicine medicine Humans skin and connective tissue diseases business.industry Macrophage Activation Syndrome Remission Induction Drug Synergism medicine.disease Infliximab stomatognathic diseases Methotrexate Macrophage activation syndrome Immunoglobulin G Immunology Drug Therapy Combination Female business Still's Disease Adult-Onset medicine.drug |
| Zdroj: | Modern rheumatology. 22(1) |
| ISSN: | 1439-7609 |
| Popis: | We report a 16-year-old female case of intractable adult-onset Still’s disease accompanied by macrophage activation syndrome, who went into full remission after switching from infliximab to etanercept. Although the disease promptly relapsed when etanercept was discontinued, she again responded fully upon the reintroduction of etanercept. Furthermore, the effect of etanercept was apparently enhanced by combining it with a sufficient dose of methotrexate. This combination therapy should be considered as one of treatment options for the disease. |
| Databáze: | OpenAIRE |
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