Vaccination for vivax malaria: targeting the invaders
| Autor: | Spencer D. Polley, Colin J. Sutherland, Louisa McRobert |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Protozoan Proteins
Antibodies Protozoan Antigens Protozoan Receptors Cell Surface law.invention Epitopes Antigen law Malaria Vaccines parasitic diseases Malaria Vivax medicine Animals Humans Merozoite Surface Protein 1 Vaccines Synthetic Polymorphism Genetic biology Vaccination medicine.disease Antigenic Variation Virology Disease Models Animal Infectious Diseases Plasmodium vivax merozoite Vaccines Subunit Vivax malaria Immunology biology.protein Recombinant DNA Parasitology Antibody Plasmodium vivax Surface protein Malaria |
| Zdroj: | Trends in Parasitology. 20:99-102 |
| ISSN: | 1471-4922 |
| DOI: | 10.1016/j.pt.2003.12.003 |
| Popis: | Among the surface-exposed antigens of the malaria parasite, those with known essential functions that can be disrupted by antibodies represent the most promising candidates for development as malaria vaccines. Two recombinant protein subunits of the Plasmodium vivax merozoite surface protein 1 have been shown to bind to reticulocytes in enzyme-linked immunosorbent assays. This article discusses the importance of such pre-clinical analyses in the validation of candidate vaccine molecules for P. vivax, given the constraints imposed by the use of primate models and the cost of producing suitable material for human trials. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect