Neuro-toxic and Reproductive Effects of BPA
| Autor: | Rosaria Meccariello, Stefania Lucia Nori, Sean Richards, Silvia Fasano, Rosanna Chianese, Jacopo Troisi, Andrea Viggiano, Maurizio Guida, Antonietta Santoro, Elizabeth Plunk, Riccardo Pierantoni |
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| Přispěvatelé: | Santoro, A, Chianese, R, Troisi, J, Richards, S, Nori, Sl, Fasano, S, Guida, M, Plunk, E, Viggiano, A, Pierantoni, R, Meccariello, R, Santoro, Antonietta, Chianese, Rosanna, Troisi, Jacopo, Richards, Sean, Nori, Stefania Lucia, Fasano, Silvia, Guida, Maurizio, Plunck, Elizabeth, Viggiano, Andrea, Pierantoni, Riccardo, Meccariello, Rosaria |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
endocrine system BPA neuronal differentiation synaptic plasticity neuroinflammation epigenetics hypothalamus HPG axis GnRH Kiss1 reproduction HPG axi Hypothalamic–pituitary–gonadal axis Gonadotropin-releasing hormone Biology Article neuroinflammation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Phenols medicine Premovement neuronal activity Animals Humans Pharmacology (medical) hypothalamus Benzhydryl Compounds neuronal differentiation Neuroinflammation Pharmacology Neurons synaptic plasticity epigenetics urogenital system Reproduction Neurotoxicity General Medicine Kiss1 medicine.disease hypothalamu BPA Psychiatry and Mental health 030104 developmental biology Neurology chemistry Hypothalamus GnRH Synaptic plasticity Neurology (clinical) HPG axis Neuroscience epigenetic 030217 neurology & neurosurgery hormones hormone substitutes and hormone antagonists Toxicant |
| Zdroj: | Current Neuropharmacology |
| ISSN: | 1875-6190 1570-159X |
| Popis: | Background:Bisphenol A (BPA) is one of the highest volume chemicals produced worldwide. It has recognized activity as an endocrine-disrupting chemical and has suspected roles as a neurological and reproductive toxicant. It interferes in steroid signaling, induces oxidative stress, and affects gene expression epigenetically. Gestational, perinatal and neonatal exposures to BPA affect developmental processes, including brain development and gametogenesis, with consequences on brain functions, behavior, and fertility.Methods:This review critically analyzes recent findings on the neuro-toxic and reproductive effects of BPA (and its analogues), with focus on neuronal differentiation, synaptic plasticity, glia and microglia activity, cognitive functions, and the central and local control of reproduction.Results:BPA has potential human health hazard associated with gestational, peri- and neonatal exposure. Beginning with BPA’s disposition, this review summarizes recent findings on the neurotoxicity of BPA and its analogues, on neuronal differentiation, synaptic plasticity, neuroinflammation, neuro-degeneration, and impairment of cognitive abilities. Furthermore, it reports the recent findings on the activity of BPA along the HPG axis, effects on the hypothalamic Gonadotropin Releasing Hormone (GnRH), and the associated effects on reproduction in both sexes and successful pregnancy.Conclusion:BPA and its analogues impair neuronal activity, HPG axis function, reproduction, and fertility. Contrasting results have emerged in animal models and human. Thus, further studies are needed to better define their safety levels. This review offers new insights on these issues with the aim to find the “fil rouge”, if any, that characterize BPA’s mechanism of action with outcomes on neuronal function and reproduction. |
| Databáze: | OpenAIRE |
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