The 'Golden Hours' Algorithm For the Management of the Multisystem Inflammatory Syndrome in Children (MIS-C)
| Autor: | Ashraf Omar, Mostafa A. El-Hodhod, Eman Ahmed Zaky, Hanan M Ibrahim, Yasmin G. El Gendy, Eman M. Fouda, Alyaa A. Kotby, Nermine H. Amr, Sanaa F. Mahmoud, Dalia H. El-Ghoneimy, Mahmoud El-Meteini, Mervat Gamal, Asmaa A. A. Alsharkawy |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
2019-20 coronavirus outbreak
Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Disease 030204 cardiovascular system & hematology medicine.disease_cause Pediatrics 03 medical and health sciences 0302 clinical medicine medicine 030212 general & internal medicine Coronavirus IVIG pediatric MIS-C algorithm Kawasaki disease business.industry lcsh:RJ1-570 COVID-19 lcsh:Pediatrics medicine.disease Pediatrics Perinatology and Child Health Immunology Perspective business |
| Zdroj: | Global Pediatric Health Global Pediatric Health, Vol 8 (2021) |
| ISSN: | 2333-794X |
| Popis: | The global concern of increasing number of children presenting with multisystem inflammatory syndrome in children (MIS-C) related to the coronavirus disease (COVID-19) has escalated the need for a case-oriented clinical approach that provides timely diagnosis and management. The aim of this study is to share our experience in managing 64 MIS-C patients of North African ethnicity guided by a risk-based algorithm. Sixty-four patients met the inclusion criteria, 19 (30%) patients were categorized as mild and moderate risk groups and cared for in an isolation ward and 45 patients who belonged to the high-risk group (70%) were admitted to the pediatric intensive care unit (PICU). Positive laboratory evidence of COVID-19 was found in 62 patients. Fever and dysfunction in 2 or more organs were confirmed in all cases (100%). Fifty patients (78%) presented with gastrointestinal symptoms, meanwhile only 10 patients (16%) had respiratory manifestations. Cardiac involvement was reported in 55 (86%) cases; hypotension and shock were found in 45 patients (70%) therein circulatory support and mechanical ventilations were needed for 45 and 13 patients respectively. Intravenous immunoglobulins (IVIG) were used for all cases and methylprednisolone was used in 60 patients (94%). Fifty-eight (91%) patients were discharged home after an average of 9 days of hospitalization. The mortality rate was 9% (6 patients). Conclusion. A single Egyptian center experience in the management of MIS-C patients guided by a proposed bed side algorithm is described. The algorithm proved to be a helpful tool for first-line responders, and helped initiate early treatment with IVIG. |
| Databáze: | OpenAIRE |
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