The effects of hormone replacement on the biomechanical properties of the uterosacral and round ligaments in the monkey model
| Autor: | Richard J. Scotti, Felicia Cosman, J. Mark Cline, Magdy S. Mikhail, J. Koudy Williams, A. Orahn Preiss-Bloom, Michael D. Vardy, Robert Lindsay, Thomas R. Gardner |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Ovariectomy Uterosacral ligament Uterus Hormone replacement Medroxyprogesterone Acetate Ethinyl Estradiol Tensile Strength Internal medicine medicine Animals Medroxyprogesterone acetate Conjugated Equine Estrogens Round Ligament of Uterus Estrogens Conjugated (USP) Ligaments business.industry Round Ligament Obstetrics and Gynecology Drug Synergism Estrogens Norethindrone Acetate Elasticity Hormones Biomechanical Phenomena Macaca fascicularis Endocrinology medicine.anatomical_structure Estrogen Female Norethindrone business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | American Journal of Obstetrics and Gynecology. 192:1741-1751 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/j.ajog.2004.10.639 |
| Popis: | The purpose of this study was to determine effects of ovariectomy (OVX) and conjugated equine estrogens plus medroxyprogesterone acetate (CEE/MPA), or ethinyl estradiol plus norethindrone acetate (EE/NA) on biomechanics of uterosacral (USL) and round (RL) ligaments in postmenopausal (PMP) monkeys.This was a randomized, triple blind, placebo-controlled study. OVX monkeys received 12 months no treatment (Pbo) (n = 19), CEE/MPA (n = 19), or EE/NA (n = 21). USL and RL step strains and stress-relaxation data were curve-fitted, giving strain-dependent tensile modulus (TM) from 0% to 30%.(1) USL: TM for both treatment groups was greater than Pbo for strains from 0% to 12% (P.04). (2) RL: TM for both treatment groups was smaller than Pbo for strains from 12% to 30% (P.05). No differences were found between treatment regimens.CEE/MPA and EE/NA both affect functional biomechanical properties by increasing tensile stiffness in the USL and decreasing it in the RL. |
| Databáze: | OpenAIRE |
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