Severely impaired microvascular reactivity in diabetic patients with an acute coronary syndrome
| Autor: | Gun Jörneskog, Nikolaos Östlund Papadogeorgos, Majid Kalani, Thomas Kahan, Mattias Bengtsson |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Acute coronary syndrome Laser Doppler fluxmetry Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Coronary Artery Disease 030204 cardiovascular system & hematology Coronary Angiography Coronary artery disease 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Interquartile range Internal medicine medicine Laser-Doppler Flowmetry Humans Angiology Aged Skin Original Investigation Aged 80 and over Glucose tolerance test medicine.diagnostic_test integumentary system business.industry Microcirculation Type 2 Diabetes Mellitus Glucose Tolerance Test Middle Aged medicine.disease Microvascular reactivity Diabetes Mellitus Type 2 Cardiology Female business Cardiology and Cardiovascular Medicine Perfusion |
| Zdroj: | Cardiovascular Diabetology |
| ISSN: | 1475-2840 |
| DOI: | 10.1186/s12933-016-0385-6 |
| Popis: | Background Microvascular function is impaired in patients with stable coronary artery disease. The aim was to study microvascular function in patients with diabetes and acute coronary syndrome (ACS). Methods Microvascular function was evaluated in 83 patients by laser Doppler fluxmetry (LDF) [PU; perfusion unit, median (interquartile range)] measuring resting LDF and peak LDF following a six min heating of the skin to 44 °C at the foot, respectively. All patients with ACS and without previously known diabetes underwent oral glucose tolerance test. Thirty-nine patients with type 2 diabetes mellitus free from coronary artery disease served as controls. Results Peak LDF was significantly (P = 0.03) lower in patients with ACS and diabetes (n = 22; 72 (52)) and diabetes without coronary artery disease (n = 39; 69 (51)) as compared to patients with ACS without diabetes (n = 46; 97 (60)), and patients without ACS (n = 15; 140 (121)), respectively. Patients with ACS (n = 68) had significantly (P = 0.04) lower peak LDF (92 (49)) as compared to patients without ACS (n = 15) (140 (121)). Conclusion Microvascular reactivity is severely impaired in patients with diabetes and ACS. Diabetes has a major influence on microvascular function in patients with coronary artery disease. |
| Databáze: | OpenAIRE |
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