Dorsal Medial Habenula Regulation of Mood-Related Behaviors and Primary Reinforcement by Tachykinin-Expressing Habenula Neurons
| Autor: | Elizabeth G. Guy, Si D. Wang, Eric E. Turner, Yun-Wei A. Hsu, Glenn Morton |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Nervous system
Male Interpeduncular nucleus substance P Gene Expression Spatial Behavior Learned helplessness Mice Transgenic Optogenetics Motor Activity interpeduncular nucleus Tissue Culture Techniques 03 medical and health sciences Diencephalon 0302 clinical medicine Helplessness Learned Tachykinins Conditioning Psychological medicine Avoidance Learning Animals Fear conditioning 030304 developmental biology Neurons 0303 health sciences Habenula Transcription Factor Brn-3A learned helplessness Depression General Neuroscience General Medicine Fear New Research fear conditioning Tail suspension test Mice Inbred C57BL Affect medicine.anatomical_structure Cognition and Behavior Septum of Brain Psychology Neuroscience Reinforcement Psychology 030217 neurology & neurosurgery |
| Zdroj: | eNeuro |
| ISSN: | 2373-2822 |
| Popis: | Animal models have been developed to investigate aspects of stress, anxiety, and depression, but our understanding of the circuitry underlying these models remains incomplete. Prior studies of the habenula, a poorly understood nucleus in the dorsal diencephalon, suggest that projections to the medial habenula (MHb) regulate fear and anxiety responses, whereas the lateral habenula (LHb) is involved in the expression of learned helplessness, a model of depression. Tissue-specific deletion of the transcription factor Pou4f1 in the dorsal MHb (dMHb) results in a developmental lesion of this subnucleus. These dMHb-ablated mice show deficits in voluntary exercise, a possible correlate of depression. Here we explore the role of the dMHb in mood-related behaviors and intrinsic reinforcement. Lesions of the dMHb do not elicit changes in contextual conditioned fear. However, dMHb-lesioned mice exhibit shorter immobility time in the tail suspension test, another model of depression. dMHb-lesioned mice also display increased vulnerability to the induction of learned helplessness. However, this effect is not due specifically to the dMHb lesion, but appears to result fromPou4f1haploinsufficiency elsewhere in the nervous system.Pou4f1haploinsufficiency does not produce the other phenotypes associated with dMHb lesions. Using optogenetic intracranial self-stimulation, intrinsic reinforcement by the dMHb can be mapped to a specific population of neurokinin-expressing habenula neurons. Together, our data show that the dMHb is involved in the regulation of multiple mood-related behaviors, but also support the idea that these behaviors do not reflect a single functional pathway. |
| Databáze: | OpenAIRE |
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