Pharmacological and biochemical studies on protective effects of mangiferin and its interaction with nitric oxide (NO) modulators in adjuvant-induced changes in arthritic parameters, inflammatory, and oxidative biomarkers in rats
| Autor: | Manju J. Chaudhary, Prafulla Chandra Tiwari, Kamlesh Kumar Pant, Rishi Pal, Rajendra Nath |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Immunology Arthritis Inflammation Pharmacology medicine.disease_cause Nitric oxide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Medicine Pharmacology (medical) Mangiferin business.industry medicine.disease 030104 developmental biology Cytokine chemistry Methotrexate medicine.symptom business Adjuvant 030217 neurology & neurosurgery Oxidative stress medicine.drug |
| Zdroj: | Inflammopharmacology. |
| ISSN: | 1568-5608 |
| Popis: | Current study was designed to evaluate protective effect of mangiferin and its interaction with low dose of nitric oxide (NO) modulators in complete Freund’s adjuvant (CFA) inoculated rats. Male wistar rats (200–300 g, n = 8 per group) were used in the study. On day ‘‘0’’ of study arthritis was induced in rats by injecting 0.2 ml CFA in sub-planter region of right hind paw of animals. Treatment with methotrexate (5 mg/kg), mangiferin (10–30 mg/kg) alone and in combination with NO modulators was given (i.p.) from days 14 to 28. After 28 days, blood and joint synovial fluid was collected for biochemical analysis and rat paws were excised to estimate MDA and SOD in tissue (paw) homogenates. CFA inoculation significantly increases (1) arthritic index, (2) ankle diameter, (3) paw volume, and (4) serum TNF-α, IL-6, IL-1β, and synovial TNF-α levels (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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