Integration of PLGA Microparticles in Collagen-Based Matrices: Tunable Scaffold Properties and Interaction Between Microparticles and Human Epithelial-Like Cells
| Autor: | Stefania Scialla, Alessandro Sannino, Ludovico Valli, V. Bucalá, L.C. Gallo, Simona Bettini, Luca Salvatore, Tiziano Verri, Marta Madaghiele, Amilcare Barca |
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| Přispěvatelé: | Gallo, L. C., Madaghiele, M., Salvatore, L., Barca, A., Scialla, S., Bettini, S., Valli, L., Verri, T., Bucalá, V., Sannino, A. |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
congenital hereditary and neonatal diseases and abnormalities Scaffold Polymers and Plastics General Chemical Engineering Plga microparticles macromolecular substances 02 engineering and technology Analytical Chemistry 03 medical and health sciences chemistry.chemical_compound CACO-2 cell Tissue engineering Highly porous Chemical Engineering (all) skin and connective tissue diseases Chemistry technology industry and agriculture collagen scaffold nutritional and metabolic diseases cell-microparticles interaction 021001 nanoscience & nanotechnology PLGA 030104 developmental biology Chemical engineering tissue engineering 0210 nano-technology PLGA microparticle |
| Zdroj: | International Journal of Polymeric Materials and Polymeric Biomaterials. 69:137-147 |
| ISSN: | 1563-535X 0091-4037 |
| Popis: | The feasibility to obtain highly porous collagen-based scaffolds (SCs) integrated with uniformly dispersed poly (lactide-co-glycolide)(PLGA) microparticles (MPs) was evaluated. PLGA-MPs were prepared by double emulsion technique and SCs with different amounts of MPs (SC/PLGA-MPs) were produced. Results showed that SC/PLGA-MPs could be successfully manufactured, the PLGA-MPs being physically retained in the SCs, without affecting the porous structure. PLGA-MPs also increased the SC hydrophilicity, acted as a mechanical reinforcement and retarded the degradation rate. In addition, the interactions between MPs and Caco-2 cells did not interfere with the correct morphological, adhesion and proliferation pathways. |
| Databáze: | OpenAIRE |
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