| Autor: |
Susanne S. Rauh, Oliver Maier, Oliver J. Gurney‐Champion, Melissa T. Hooijmans, Rudolf Stollberger, Aart J. Nederveen, Gustav J. Strijkers |
| Přispěvatelé: |
Biomedical Engineering and Physics, Graduate School, AMS - Musculoskeletal Health, AMS - Sports, Radiology and Nuclear Medicine, CCA - Imaging and biomarkers, AMS - Ageing & Vitality, ACS - Diabetes & metabolism, ACS - Atherosclerosis & ischemic syndromes, ACS - Heart failure & arrhythmias |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
NMR in biomedicine. John Wiley and Sons Ltd |
| ISSN: |
0952-3480 |
| Popis: |
Intravoxel incoherent motion (IVIM) imaging and diffusion tensor imaging (DTI) facilitate noninvasive quantification of tissue perfusion and diffusion. Both are promising biomarkers in various diseases and a combined acquisition is therefore desirable. This comes with challenges, including noisy parameter maps and long scan times, especially for the perfusion fraction f and pseudo-diffusion coefficient D*. A model-based reconstruction has the potential to overcome these challenges. As a first step, our goal was to develop a model-based reconstruction framework for IVIM and combined IVIM-DTI parameter estimation. The IVIM and IVIM-DTI models were implemented in the PyQMRI model-based reconstruction framework and validated with simulations and in vivo data. Commonly used voxel-wise nonlinear least-squares fitting was used as the reference. Simulations with the IVIM and IVIM-DTI models were performed with 100 noise realizations to assess accuracy and precision. Diffusion-weighted data were acquired for IVIM reconstruction in the liver (n = 5), as well as for IVIM-DTI in the kidneys (n = 5) and lower-leg muscles (n = 6) of healthy volunteers. The median and interquartile range (IQR) values of the IVIM and IVIM-DTI parameters were compared to assess bias and precision. With model-based reconstruction, the parameter maps exhibited less noise, which was most pronounced in the f and D* maps, both in the simulations and in vivo. The bias values in the simulations were comparable between model-based reconstruction and the reference method. The IQR was lower with model-based reconstruction compared with the reference for all parameters. In conclusion, model-based reconstruction is feasible for IVIM and IVIM-DTI and improves the precision of the parameter estimates, particularly for f and D* maps. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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