Evaluation on clinical efficacy of Fuzheng Jiedu Huayu Decoction combined with antibiotics in the treatment of pneumonia in the elderly - A multi-center, double-blind, parallel, randomized controlled trial
| Autor: | Hongri Xu, Pingan Zhou, Ruifu Hao, Miao Cheng, Huiping Su, Liang-Duo Jiang, Hanlin Wei, Mingzhe Wang, Quan Ming Tan, Jie Ma, Shaozhong Zhou, Ren-Yi Yin, Caihua Wang, Xianhai Chen, Chuanyun Ren, Jiao Yang, Cheng-Xiang Wang, Meng Li, Lishan Zhang, Hui Luo, Cuiling Feng, Shengxian Wu |
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| Rok vydání: | 2017 |
| Předmět: |
Complementary and Manual Therapy
Male medicine.medical_specialty medicine.drug_class Antibiotics Decoction 010502 geochemistry & geophysics 01 natural sciences law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine medicine Pneumonia Bacterial Humans 030212 general & internal medicine Adverse effect 0105 earth and related environmental sciences Aged Advanced and Specialized Nursing Aged 80 and over business.industry Mortality rate Standard treatment medicine.disease Anti-Bacterial Agents Pneumonia Treatment Outcome Complementary and alternative medicine Arterial blood Female Radiography Thoracic business Drugs Chinese Herbal |
| Zdroj: | Complementary therapies in medicine. 37 |
| ISSN: | 1873-6963 |
| Popis: | To evaluate the efficacy and safety of Fuzheng Jiedu Huayu Decoction (FJHD) in treating pneumonia in the elderly.Adopting a multi-center, double-blind, parallel, randomized controlled trial, 284 elderly pneumonia patients were enrolled and randomly allocated to the standard treatment with FJHD (treatment group, TG) and the standard treatment with placebo group (control group, CG). Efficacy and safety was evaluated through mortality rate, curative rate, symptom improvement, chest X-ray (CXR) lesion absorption, arterial blood gas (ABG), peripheral blood leukocyte count (PBLC) and adverse events.There was no significant difference in mortality rate between both groups (P 0.05). TG significantly enhanced the curative rate of a 2-week treatment course (P 0.05). Compared with CG, TG significantly decreased the expectoration score during the first and second week of treatment (P 0.05). During the first week, improvement in expectoration was conducive to airway patency. During the second week, wheezing, shortness of breath and other symptoms were also significantly improved. During the third week, body temperature was stable. TG improved lesion absorption with Pneumonia Severity Index (PSI) class II (P 0.05) and SMART-COP score 1 (P 0.05). TG significantly decreased the arterial carbon dioxide partial pressure after a 1-week treatment. There were no serious adverse events in TG.Standard anti-infection treatment with FJHD is a safe and reliable method of treating elderly patients with pneumonia, improving the curative effect after a 2-week treatment course, ameliorating expectoration and promoting the absorption of pneumonia lesions. |
| Databáze: | OpenAIRE |
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