Surveillance Rate and its Impact on Survival of Hepatocellular Carcinoma Patients in South Korea: A Cohort Study
Autor: | Jin Wook Kim, Sook Hyang Jeong, Jung Wha Chung, Beom Hee Kim, Sanghyuk Im, Chung Seop Lee, Ju Hyun Lee, Eun Sun Jang |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Male Cancer Research medicine.medical_specialty Health Knowledge Attitudes Practice Carcinoma Hepatocellular Survival Hepatocellular carcinoma Improved survival Cohort Studies Tertiary Care Centers 03 medical and health sciences 0302 clinical medicine Internal medicine Surveys and Questionnaires Republic of Korea medicine Humans Prospective Studies Stage (cooking) Early Detection of Cancer Liver imaging Aged Related factors Surveillance business.industry Proportional hazards model Liver Neoplasms Middle Aged medicine.disease Survival Analysis digestive system diseases 030104 developmental biology Oncology 030220 oncology & carcinogenesis Population Surveillance Cohort Liver cirrhosis Screening Regression Analysis Original Article Female business Cohort study |
Zdroj: | Cancer Research and Treatment : Official Journal of Korean Cancer Association |
ISSN: | 2005-9256 1598-2998 |
Popis: | PURPOSE Though regular surveillance of hepatocellular carcinoma (HCC) for high-risk patients is widely recommended, its rate and effectiveness are not clear. The aim of this study is to investigate the actual rate of HCC surveillance and its related factors and to clarify its impact on survival in a Korean HCC cohort. Materials and Methods From 2012 to 2015, 319 newly diagnosed HCC patients were prospectively enrolled at a tertiary hospital. Patient interviews based on a structured questionnaire survey were conducted. Surveillance was defined as liver imaging test ≥ 2 times with at least 3-month interval within 2 years prior to HCC diagnosis. RESULTS Surveillance rate was 39.8%. Of the HCC patients with high-risk factors, only 182 (57.1%) had knowledge for the need for regular surveillance, and 141 (44.2%) had the accurate information about the method (ultrasound-based study). Surveillance group showed a higher proportion of early HCC (p < 0.001) and a longer overall survival (p < 0.001) compared to non-surveillance group. The multivariable Cox regression analysis indicated Child-Pugh class A, history of anti-viral therapy, low serum α-fetoprotein level, non-advanced Barcelona Clinic Liver Cancer stage as independent predictors of overall survival, while regular surveillance was not (p=0.436). CONCLUSION Less than half of the newly diagnosed Korean HCC patients were under surveillance and the accurate perception for the need of HCC surveillance was insufficient. Of those under surveillance, most patients were diagnosed with early stage HCC, which led to the improved survival. Comprehensive efforts to optimize the surveillance program for the target population are warranted. |
Databáze: | OpenAIRE |
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