Protein degradation, as with protein synthesis, is required during not only long-term spatial memory consolidation but also reconsolidation

Autor:	Lionel Moulédous, Julien Artinian, Xavier De Jaeger, Pascal Roullet, Bernard Frances, Anne-Marie T. McGauran
Přispěvatelé:	Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut de pharmacologie et de biologie structurale (IPBS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées
Rok vydání:	2008
Předmět:	Male MESH: Hippocampus Long-Term Potentiation MESH: Neurons Morris water navigation task Hippocampal formation Hippocampus Mice chemistry.chemical_compound 0302 clinical medicine Protein biosynthesis MESH: Animals MESH: Nerve Tissue Proteins MESH: Memory Anisomycin Neurons Protein Synthesis Inhibitors 0303 health sciences Consolidation (soil) General Neuroscience [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Memory consolidation Psychology MESH: Space Perception Lactacystin MESH: Anisomycin Nerve Tissue Proteins Cysteine Proteinase Inhibitors Protein degradation MESH: Cysteine Proteinase Inhibitors 03 medical and health sciences MESH: Acetylcysteine MESH: Long-Term Potentiation Memory Animals Maze Learning MESH: Mice 030304 developmental biology Communication MESH: Protein Synthesis Inhibitors business.industry MESH: Maze Learning MESH: Male Acetylcysteine chemistry Space Perception business Neuroscience 030217 neurology & neurosurgery
Zdroj:	European Journal of Neuroscience European Journal of Neuroscience, Wiley, 2008, 27 (11), pp.3009-19. ⟨10.1111/j.1460-9568.2008.06262.x⟩
ISSN:	1460-9568 0953-816X
DOI:	10.1111/j.1460-9568.2008.06262.x
Popis:	The formation of long-term memory requires protein synthesis, particularly during initial memory consolidation. This process also seems to be dependant upon protein degradation, particularly degradation by the ubiquitin-proteasome system. The aim of this study was to investigate the temporal requirement of protein synthesis and degradation during the initial consolidation of allocentric spatial learning. As memory returns to a labile state during reactivation, we also focus on the role of protein synthesis and degradation during memory reconsolidation of this spatial learning. Male CD1 mice were submitted to massed training in the spatial version of the Morris water maze. At various time intervals after initial acquisition or after a reactivation trial taking place 24 h after acquisition, mice received an injection of either the protein synthesis inhibitor anisomycin or the protein degradation inhibitor lactacystin. This injection was performed into the hippocampal CA3 region, which is specifically implicated in the processing of spatial information. Results show that, in the CA3 hippocampal region, consolidation of an allocentric spatial learning task requires two waves of protein synthesis taking place immediately and 4 h after acquisition, whereas reconsolidation requires only the first wave. However, for protein degradation, both consolidation and reconsolidation require only one wave, taking place immediately after acquisition or reactivation, respectively. These findings suggest that protein degradation is a key step for memory reconsolidation, as for consolidation. Moreover, as protein synthesis-dependent reconsolidation occurred faster than consolidation, reconsolidation did not consist of a simple repetition of the initial consolidation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c88e9029db37179575a0979a4c49c699 https://doi.org/10.1111/j.1460-9568.2008.06262.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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