Microhemodynamic indices to evaluate the effectiveness of herbal medicine in diabetes: A comparison between alpha-mangostin and curcumin in the retina of type 2 diabetic rats

Autor:	Niimi Hideyuki, Chonticha Areebambud, Amporn Jariyapongskul
Rok vydání:	2018
Předmět:	0301 basic medicine Male Mean arterial pressure Curcumin Physiology Herbal Medicine Xanthones Type 2 diabetes Pharmacology Retina Diabetes Mellitus Experimental Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Physiology (medical) Diabetes mellitus Medicine Animals Alpha mangostin business.industry Hemodynamics Retinal Hematology medicine.disease Streptozotocin Rats 030104 developmental biology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Cardiology and Cardiovascular Medicine business medicine.drug
Zdroj:	Clinical hemorheology and microcirculation. 69(4)
ISSN:	1875-8622
Popis:	OBJECTIVE This study was aimed to develop microhemodynamic indices to evaluate the effectiveness of herbal medicine in diabetic tissues. METHODS Male Sprague-Dawley rats were divided into four groups: normal control rats (Control), type 2 diabetic rats without (DM2) and with supplementation of alpha mangostin (DM2-MG) or curcumin (DM2-CUR). Alpha-mangostin or curcumin (200 mg/kg BW) were fed followed by i.p. injection of streptozotocin (STZ). Mean arterial pressure (MAP) and retinal blood flow (RBF) were measured and retinal flow resistance (RFR) was calculated. Three indices were developed to evaluate the effectiveness of herbal medicines in RFR-MAP diagram based on experimental data of MAP and RFR in type 2 diabetic rats. These indices are α, β, and γ where α is a ratio of reduction in MAP, β is a ratio of reduction in RFR increasing with MAP increase, and γ indicates a ratio of reduction in RFR. RESULTS The elevated MAP and RFR and decreased RBF were observed in DM2 rats.Interestingly, alpha-mangostin or curcumin supplementation significantly increased RBF while decreased MAP and RFR. Using α, β and γ indices, it was found that alpha-mangostin is more effective than curcumin in type 2 diabetic retina. CONCLUSIONS These microhemodynamic indices may be useful to compare various herbal medicines in different tissues.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8848cd62b15b61fd099fe77314ff815 https://pubmed.ncbi.nlm.nih.gov/29332034 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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