Precision medicine approach to genetic cardiomyopathy
| Autor: | Benjamin Meder, Hugo A. Katus, K Filonenko |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cardiomyopathy Dilated DNA Mutational Analysis Cardiomyopathy Improved survival Genome-wide association study Disease 030204 cardiovascular system & hematology Bioinformatics 03 medical and health sciences 0302 clinical medicine Genetic etiology medicine Humans Clustered Regularly Interspaced Short Palindromic Repeats Genetic Predisposition to Disease Precision Medicine Genetic testing medicine.diagnostic_test business.industry Arrhythmias Cardiac Precision medicine medicine.disease Survival Rate 030104 developmental biology Death Sudden Cardiac Treatment strategy Cardiology and Cardiovascular Medicine business Genome-Wide Association Study Targeted Gene Repair |
| Zdroj: | Herz. 42(5) |
| ISSN: | 1615-6692 |
| Popis: | Precision medicine aims to achieve improved survival by strategies that recognize the genetic and phenotypic individuality of patients and stratify treatment accordingly. Genetic cardiomyopathies represent an ideal disease group to fully embark on this concept: they are in total frequent diseases with a marked morbidity and mortality and there is ample knowledge about their predisposing genetic factors and associated functional mechanisms. The current review highlights the genetic etiology and gives examples of the diverse treatment strategies that are envisaged in the future. |
| Databáze: | OpenAIRE |
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