Intranasal Antiviral Drug Delivery and Coronavirus Disease 2019 (COVID‐19): A State of the Art Review
| Autor: | Thomas S. Higgins, Elisa A. Illing, Kevin J. Sokoloski, Benjamin P. Anthony, Nathan Hughes, Bree Weaver, Jonathan Y. Ting, Arthur W. Wu |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
2019-20 coronavirus outbreak Coronavirus disease 2019 (COVID-19) medicine.drug_class Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Pneumonia Viral medicine.disease_cause Antiviral Agents Betacoronavirus 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine medicine Humans 030223 otorhinolaryngology Intensive care medicine Pandemics Administration Intranasal 030304 developmental biology Coronavirus 0303 health sciences SARS-CoV-2 business.industry COVID-19 State of the art review Otorhinolaryngology Surgery Nasal administration Antiviral drug Coronavirus Infections business |
| Zdroj: | Otolaryngology–Head and Neck Surgery. 163:682-694 |
| ISSN: | 1097-6817 0194-5998 |
| DOI: | 10.1177/0194599820933170 |
| Popis: | To provide a state of the art review of intranasal antiviral drug delivery and to discuss current applications, adverse reactions, and future considerations in the management of coronavirus disease 2019 (COVID-19).PubMed, Embase, and Clinicaltrials.gov search engines.A structured search of the current literature was performed of dates up to and including April 2020. Search terms were queried as related to topics of antiviral agents and intranasal applications. A series of video conferences was convened among experts in otolaryngology, infectious diseases, public health, pharmacology, and virology to review the literature and discuss relevant findings.Intranasal drug delivery for antiviral agents has been studied for many years. Several agents have broad-spectrum antiviral activity, but they still require human safety and efficacy trials prior to implementation. Intranasal drug delivery has potential relevance for future clinical trials in the settings of disease spread prevention and treatment of SARS-CoV-2 and other viral diseases.Intranasal drug delivery represents an important area of research for COVID-19 and other viral diseases. The consideration of any potential adverse reactions is paramount. |
| Databáze: | OpenAIRE |
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