Targeted cognitive game training enhances cognitive performance in multiple sclerosis patients treated with interferon beta 1-a
| Autor: | Gil Harari, Roy Aloni, Mark Dolev, Ran Achiron, Anat Achiron, Keren Gutman, Shay Menascu, Franck Tarpin-Bernard, David Magalashvili, Sapir Dreyer Alster |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Plasticity Interferon-beta-1-a Neurosciences. Biological psychiatry. Neuropsychiatry Health Informatics Neuropsychological Tests Multiple sclerosis Cognition Physical medicine and rehabilitation Executive function medicine Humans Training Cognitive Dysfunction Prospective Studies Effects of sleep deprivation on cognitive performance Interferon beta business.industry Research Rehabilitation Interferon-beta medicine.disease Information processing speed Games business RC321-571 |
| Zdroj: | Journal of NeuroEngineering and Rehabilitation, Vol 18, Iss 1, Pp 1-8 (2021) Journal of NeuroEngineering and Rehabilitation |
| ISSN: | 1743-0003 |
| DOI: | 10.1186/s12984-021-00968-3 |
| Popis: | Background Prevention of cognitive decline in Multiple Sclerosis (MS) is of major importance. We explored the effect of a 6 months computerized game training program on cognitive performance in MS patients with mild cognitive impairment. Methods This was a single-center, randomized prospective study. We enrolled in this study 100 eligible MS patients treated with Interferon-beta-1a (Rebif). All had mild cognitive impairment in either executive function or information processing speed. Patients were randomized 1:1 to either use the cognitive games platform by HappyNeuron (HN) or receive no intervention. Executive function and information processing speed scores were measured at 3 and 6 months from baseline to evaluate the effect of game training on cognitive scores. Results In both executive function and information processing speed, the game Training group showed significant improvement after 3 and 6 months. The Non-Training group showed mild deterioration in both domains at 3 months, and further deterioration that became significant at 6 months in executive function. Furthermore, at 6 months, the percent of patients in the Training group that improved or remained stable in both cognitive domains was significantly higher compared to the Non-Training group. Conclusions Our findings suggest that cognitive game training has a beneficial effect on cognitive performance in MS patients suffering from mild cognitive impairment. While further evaluation is required to assess the longevity of that effect, we nonetheless recommend to MS patients to be engaged in cognitive gaming practice as part of a holistic approach to treating their condition. |
| Databáze: | OpenAIRE |
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