Prenatal Household Air Pollution Alters Cord Blood Mononuclear Cell Mitochondrial DNA Copy Number: Sex-Specific Associations
| Autor: | Seth Owusu-Agyei, Darby Jack, Seyram Kaali, Patrick L. Kinney, Steven N. Chillrud, Kwaku Poku Asante, Kenneth Ayuurebobi Ae-Ngibise, Ashlinn Quinn, Blair J. Wylie, Andrea A. Baccarelli, Katrin Burkart, Alison Gladding Lee, Rupert Delimini, Jones Opoku-Mensah, Lisa Hu, Ellen Boamah-Kaali |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Mitochondrial DNA Health Toxicology and Mutagenesis household air pollution lcsh:Medicine 010501 environmental sciences medicine.disease_cause DNA Mitochondrial Ghana 01 natural sciences Peripheral blood mononuclear cell Article Andrology Young Adult 03 medical and health sciences Sex Factors Pregnancy Humans Medicine oxidative stress Cooking 0105 earth and related environmental sciences Carbon Monoxide business.industry lcsh:R Infant Newborn Pregnancy Outcome Public Health Environmental and Occupational Health Fetal Blood Sex specific 3. Good health 030104 developmental biology Real-time polymerase chain reaction mitochondrial DNA copy number fetal programming Socioeconomic Factors 13. Climate action Air Pollution Indoor Cord blood Biomarker (medicine) Female Analysis of variance sex-specific effects business Biomarkers Oxidative stress |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 16 Issue 1 International Journal of Environmental Research and Public Health, Vol 16, Iss 1, p 26 (2018) |
| ISSN: | 1660-4601 1661-7827 |
| DOI: | 10.3390/ijerph16010026 |
| Popis: | Background: Associations between prenatal household air pollution (HAP) exposure or cookstove intervention to reduce HAP and cord blood mononuclear cell (CBMC) mitochondrial deoxyribonucleic acid copy number (mtDNAcn), an oxidative stress biomarker, are unknown. Materials and Methods: Pregnant women were recruited and randomized to one of two cookstove interventions, including a clean-burning liquefied petroleum gas (LPG) stove, or control. Prenatal HAP exposure was determined by serial, personal carbon monoxide (CO) measurements. CBMC mtDNAcn was measured by quantitative polymerase chain reaction. Multivariable linear regression determined associations between prenatal CO and cookstove arm on mtDNAcn. Associations between mtDNAcn and birth outcomes and effect modification by infant sex were explored. Results: LPG users had the lowest CO exposures (p = 0.02 by ANOVA). In boys only, average prenatal CO was inversely associated with mtDNAcn (&beta = -14.84, SE = 6.41, p = 0.03, per 1ppm increase in CO). When examined by study arm, LPG cookstove had the opposite effect in all children (LPG &beta = 19.34, SE = 9.72, p = 0.049), but especially boys (&beta = 30.65, SE = 14.46, p = 0.04), as compared to Control. Increased mtDNAcn was associated with improved birth outcomes. Conclusions: Increased prenatal HAP exposure reduces CBMC mtDNAcn, suggesting cumulative prenatal oxidative stress injury. An LPG stove intervention may reverse this effect. Boys appear most susceptible. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|