Grandparents’ age and the risk of Down's syndrome in Norway
| Autor: | Rolv T. Lie, Method R. Kazaura, Rolv Skjærven |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
medicine.medical_specialty Down syndrome Offspring Paternal Age Pregnancy Risk Factors Epidemiology medicine Humans Family Registries Risk factor Aged Norway business.industry Confounding Age Factors Obstetrics and Gynecology Grandparent General Medicine Odds ratio Middle Aged medicine.disease Logistic Models Female Down Syndrome business Maternal Age Demography |
| Zdroj: | Acta Obstetricia et Gynecologica Scandinavica. 85:236-240 |
| ISSN: | 1600-0412 0001-6349 |
| Popis: | Background. High maternal age is a well-recognized risk factor for Down's syndrome. There are also several studies of a possible effect of paternal age, but no consistent evidence of an association is found. Less is known about any effects of the age of grandparents. Objective. To assess whether maternal or paternal grandparents’ age is associated with the risk of Down's syndrome. Methods. We used logistic regression analyses with data from the Medical Birth Registry of Norway, adjusting for possible confounding factors. Results. We found no evidence of an association with the risk of Down's syndrome either for a maternal grandmother's age (odds ratio 0.9, 95% confidence interval 0.6–1.5 per 10-year increase in grandmother's age) or for any of the other grandparents’ age. Conclusions. High maternal age remains the only well-established age-related risk factor for Down's syndrome. There is little evidence that the increased risk represented by older mothers is passed on to offspring of her non-affected dau... |
| Databáze: | OpenAIRE |
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