Isolation, structural assignment and synthesis of (SE)-2-methyloctyl 3-(4-methoxyphenyl) propenoate from the marine soft coral Sarcophyton ehrenbergi
| Autor: | Yenamandra Venkateswarlu, Richard A. Bunce, Chitturi Bhujanga Rao, Tatipamula Vinay Bharadwaj, Tuniki Venugopal Raju, Dokuburra Chanti Babu, Kalivendi Shasi Vardhan, Dudem Srikanth |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Stereochemistry Metabolite Coral Antineoplastic Agents Breast Neoplasms Marine Biology Plant Science Biochemistry Analytical Chemistry HeLa chemistry.chemical_compound DU145 Bioassay Animals Humans Nuclear Magnetic Resonance Biomolecular Oxazolidinones biology Molecular Structure Organic Chemistry Sarcophyton ehrenbergi Stereoisomerism biology.organism_classification Anthozoa In vitro chemistry Female Enantiomer Diterpenes Drug Screening Assays Antitumor Propionates HeLa Cells |
| Zdroj: | Natural product research. 29(1) |
| ISSN: | 1478-6427 |
| Popis: | A new metabolite 1 has been isolated from the marine soft coral Sarcophyton ehrenbergi along with two known diterpenoids 2 and 3 and cholesterol 4. The structure of 1 was determined by means of detailed spectroscopic analysis and unambiguously confirmed to have the S configuration by the synthesis of both enantiomers using 4-benzyl-2-oxazolidinone auxiliaries. (S)- and (R)-1, 3 and some of the synthetic intermediates were evaluated for cytotoxic activity against human lung cancer (A549), prostate cancer (DU145), cervical cancer (HeLa) and breast cancer (MCF-7) cell lines in an in vitro bioassay. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|