On the Production of Chitosan-Coated Polycaprolactone Nanoparticles in a Confined Impinging Jet Reactor
| Autor: | Gladys E. Granero, Antonello Barresi, Maria Julia Mora, Davide Fissore, Tereza Zelenková |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Materials science
Polymers Polyesters Evaporation Pharmaceutical Science Nanoparticle 02 engineering and technology Poloxamer 010402 general chemistry 01 natural sciences Chitosan chemistry.chemical_compound solvent displacement nanoparticles nanotechnology chitosan particle size stability confined impinging jet reactor solvent displacement Zeta potential NANOPARTICLES Particle Size CHITOSAN Drug Carriers nanotechnology STABILITY Otras Ciencias Químicas NANOTECHNOLOGY Ciencias Químicas PARTICLE SIZE CONFINED IMPINGING JET REACTOR stability 021001 nanoscience & nanotechnology 0104 chemical sciences Particle aggregation chemistry Chemical engineering Polyvinyl Alcohol Polycaprolactone Solvents Particle Nanoparticles Particle size 0210 nano-technology SOLVENT DISPLACEMENT CIENCIAS NATURALES Y EXACTAS confined impinging jet reactor |
| Popis: | This work is focused on the synthesis of polycaprolactone nanoparticles, coated with chitosan, in a confined impinging jet reactor using the solvent displacement method. The role of the various reacting species was investigated, evidencing that a biocompatible polymer, for example, polycaprolactone, is required to support chitosan to obtain a monomodal particle size distribution, with low particle diameters. A surfactant is required to reduce the nanoparticle size (down to a mean diameter of about 260 nm) and obtain a positive zeta potential (about +31 mV), perfectly suitable for pharmaceutical applications. Different surfactants were tested, and Poloxamer 388 appeared to be preferable to polyvinyl alcohol. The effect of the concentration of Poloxamer 388 (in the range 0.5-5 mg mL−1) and of chitosan (in the range 1.5-5 mg mL−1) on both the mean particle size and zeta potential was also investigated, evidencing that chitosan concentration has the strongest effect on both parameters. Finally, the effect of solvent evaporation, quenching and feed flow rate was investigated, showing that the evaporation stage does not affect particle characteristics, quenching is required to avoid particle aggregation, and a minimum liquid flow rate of 80 mL min−1 is required in the considered reactor to minimize the particle size. Fil: Zelenkova, Tereza. Politecnico di Torino. Dipartimento di Scienza Applicata e Tecnologia; Italia Fil: Mora, Maria Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina Fil: Barresi, Antonello A.. Politecnico di Torino. Dipartimento di Scienza Applicata e Tecnologia; Italia Fil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina Fil: Fissore, Davide. Politecnico di Torino. Dipartimento di Scienza Applicata e Tecnologia; Italia |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|