Acromegaly Accompanied by Turner Syndrome with 47,XXX/45,X/46,XX Mosaicism
| Autor: | Kiyoshi Hashizume, Masanori Yamazaki, Shin-ichi Nishio, Takahide Miyamoto, Miyuki Katai, Ai Sato, Teiji Takeda |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adenoma
Adult medicine.medical_specialty endocrine system diseases Turner syndrome Cubitus valgus Pituitary neoplasm Short stature Diagnosis Differential Pituitary adenoma Internal medicine Acromegaly Internal Medicine medicine 47 XXX Humans Pituitary Neoplasms In Situ Hybridization Fluorescence Chromosomes Human X business.industry General Medicine medicine.disease Magnetic Resonance Imaging Premature ovarian failure Endocrinology mosaicism Growth Hormone acromegaly Female medicine.symptom business |
| Zdroj: | INTERNAL MEDICINE. 48(6):447-453 |
| ISSN: | 0918-2918 |
| Popis: | A 33-year-old woman was hospitalized for examination of edematous laryngopharynx. She was acromegalic. A pituitary adenoma with elevated serum levels of growth hormone (GH) and insulin-like growth factor-I (IGF-I) was detected, indicating acromegaly caused by GH-secreting pituitary adenoma. Multiple pigmented nevi were also noted without overt short stature and cubitus valgus. Chromosome analysis revealed that she had contracted Turner syndrome with 47,XXX/45,X/46,XX mosaicism. Transsphenoidal resection of the tumor decreased serum GH and IGF-I levels, but the edema was not improved. Both premature ovarian failure and hypertension appeared after surgery. This case may indicate the important relationships between GH/IGF-I and Turner syndrome. Article INTERNAL MEDICINE. 48(6):447-453 (2009) |
| Databáze: | OpenAIRE |
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