Role of Osteoprotegerin and Receptor Activator of Nuclear Factor-κB Ligand in Bone Loss Related to Advanced Chronic Obstructive Pulmonary Disease
| Autor: | Vera Nevzorova, Ludmila Ugay, Yuliya V. Maistrovskaia, Kochetkova Ea |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male musculoskeletal diseases medicine.medical_specialty Bone density Chronic Obstructive Pulmonary Disease Osteoporosis lcsh:Medicine Pulmonary function testing Bone remodeling 03 medical and health sciences Pulmonary Disease Chronic Obstructive 0302 clinical medicine Osteoprotegerin Bone Density Internal medicine medicine Humans COPD biology business.industry Tumor Necrosis Factor-alpha RANK Ligand lcsh:R Tumor Necrosis Factor Receptors Receptor Activator of Nuclear Factor-κB Ligand General Medicine Middle Aged medicine.disease Respiratory Function Tests 030104 developmental biology Endocrinology Cross-Sectional Studies 030228 respiratory system RANKL biology.protein Osteocalcin Original Article business |
| Zdroj: | Chinese Medical Journal, Vol 129, Iss 14, Pp 1696-1703 (2016) Chinese Medical Journal |
| ISSN: | 0366-6999 |
| Popis: | Background: Osteoporosis is a common complication of chronic obstructive pulmonary disease (COPD). Recent clinical and biological researches have increasingly delineated the biomolecular pathways of bone metabolism regulation in COPD. We extended this work by examining the specific association and potential contribution of the osteoprotegerin (OPG)/receptor activator of nuclear factor-κB ligand (RANKL) axis to the pathogenesis of osteoporosis in advanced COPD. The aim of this study was to assess the relationships of serum OPG, RANKL, and tumor necrosis factor-alpha (TNF-α) with bone turnover in men with very severe COPD. Methods: Pulmonary function, T-score at the lumbar spine (LS) and femoral neck (FN), serum OPG, RANKL, soluble receptor of tumor necrosis factor-alpha-I and II (sTNFR-I, sTNFR-II), osteocalcin (OC), and β-CrossLaps (βCL) levels were measured in 45 men with very severe stage COPD and 36 male non-COPD volunteers. COPD patients and healthy controls were compared using an independent t-test and Mann–Whitney U-test. The Pearson coefficient was used to assess the relationships between variables. Results: OPG and OC were lower in male COPD patients than in control subjects whereas RANKL, serum βCL, TNF-α, and its receptors were higher. OPG directly correlated with forced expiratory volume in 1 s (FEV1) % predicted (r = 0.46, P < 0.005), OC (r = 0.34, P < 0.05), LS (r = 0.56, P < 0.001), and FN T-score (r = 0.47, P < 0.01). In contrast, serum RANKL inversely associated with LS and FN T-score (r = −0.62, P < 0.001 and r = −0.48, P < 0.001) but directly correlated with βCL (r = 0.48, P < 0.001). In addition, OPG was inversely correlated with RANKL (r = −0.39, P < 0.01), TNF-α (r = −0.56, P < 0.001), and sTNFR-I (r = −0.40, P < 0.01). Conclusion: Our results suggest that serum OPG and RANKL levels are inversely associated with bone loss in men with advanced stage COPD. |
| Databáze: | OpenAIRE |
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