Unilateral versus bilateral botulinum toxin injections in adductor spasmodic dysphonia in a large cohort
| Autor: | Steven Bielamowicz, Ishaan Dharia |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Weakness Laryngology Side effect Injections Intramuscular Spasmodic dysphonia 03 medical and health sciences 0302 clinical medicine Tremor medicine Humans Botulinum Toxins Type A 030223 otorhinolaryngology Aged Retrospective Studies Aged 80 and over business.industry Retrospective cohort study Middle Aged Dysphonia Botulinum toxin Dysphagia Treatment Outcome Neuromuscular Agents Otorhinolaryngology 030220 oncology & carcinogenesis Anesthesia Female Laryngeal Muscles medicine.symptom business medicine.drug Cohort study |
| Zdroj: | The Laryngoscope. 130:2659-2662 |
| ISSN: | 1531-4995 0023-852X |
| DOI: | 10.1002/lary.28457 |
| Popis: | Objectives/hypothesis The primary treatment of adductor spasmodic dysphonia is repeated injections of botulinum toxin type A (Botox) into the thyroarytenoid muscles. Dosing can be performed into either one or both thyroarytenoid muscles. The objective of this study was to evaluate the treatment effect and side effect profile across a large number of injections. This study was performed previously in 2002 on 45 patients. Study design Individual cohort study. Methods This is retrospective study of all patients with adductor spasmodic dysphonia with and without tremor treated by the senior laryngologist at George Washington University. In the current study, 272 patients (214 females and 58 males) were included in the current analysis. Duration of effects and side effects (vocal weakness and liquid dysphagia) were recorded into a database for each patient after each injection. These data were analyzed using χ2 analysis. Results A total of 4,023 injections (2,708 bilateral and 1,315 unilateral) were evaluated in this study. Optimal effect duration (≥3 months) was more commonly seen in the bilaterally injected patients (55%) compared to the unilaterally injected patients (47%) (P = .0001). Optimal side effect duration (≤2 weeks) was better for the unilaterally injected patients (77%) compared to the bilaterally injected patients (73%) (P = .023). Having both optimal effect and side effect in the same injection was more commonly seen in the bilaterally injected patients (36%) compared to the unilaterally injected patients (33%) (P = .0228). Conclusions This study shows that bilateral injections of Botox are more effective in producing optimal effect/side effect profiles. Level of evidence 2b Laryngoscope, 130:2659-2662, 2020. |
| Databáze: | OpenAIRE |
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