Design strategies of hybrid metallic nanoparticles for theragnostic applications
| Autor: | Martin Soucé, Juliette Gautier, Katel Hervé-Aubert, Igor Chourpa, Emilie Allard-Vannier |
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| Přispěvatelé: | Nanomédicaments et Nanosondes, EA 6295 (NMNS), Université de Tours, Université de Tours (UT) |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Polymers
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging MESH: Ferric Compounds/chemistry Metal Nanoparticles Nanoparticle 02 engineering and technology Ferric Compounds MESH: Colloids/chemical synthesis General Materials Science MESH: Static Electricity Targeting ligands Drug Carriers 0303 health sciences Coating materials MESH: Hydrophobic and Hydrophilic Interactions 021001 nanoscience & nanotechnology MESH: Antineoplastic Agents/chemistry MESH: Drug Carriers Mechanics of Materials Colloidal gold MESH: Doxorubicin/chemistry MESH: Doxorubicin/administration & dosage 0210 nano-technology Hydrophobic and Hydrophilic Interactions Materials science Nanostructure Surface Properties Static Electricity MESH: Liposomes/chemistry Antineoplastic Agents Bioengineering Nanotechnology MESH: Metal Nanoparticles/chemistry 03 medical and health sciences MESH: Polymers/chemistry [SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication [CHIM.ANAL]Chemical Sciences/Analytical chemistry Colloids Electrical and Electronic Engineering Metal nanoparticles [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials 030304 developmental biology MESH: Surface Properties Mechanical Engineering General Chemistry MESH: Antineoplastic Agents/administration & dosage Doxorubicin Liposomes Surface modification Nanocarriers |
| Zdroj: | Nanotechnology Nanotechnology, Institute of Physics, 2013, 24 (43), pp.432002. ⟨10.1088/0957-4484/24/43/432002⟩ |
| ISSN: | 0957-4484 1361-6528 |
| DOI: | 10.1088/0957-4484/24/43/432002⟩ |
| Popis: | International audience; Metallic nanoparticles (MNPs) such as iron oxide and gold nanoparticles are interesting platforms to build theragnostic nanocarriers which combine both therapeutic and diagnostic functions within a single nanostructure. Nevertheless, their surface must be functionalized to be suitable for in vivo applications. Surface functionalization also provides binding sites for targeting ligands, and for drug loading. This review focuses on the materials and surface chemistry used to build hybrid nanocarriers that are inorganic cores functionalized with organic materials. The surface state of the MNPs largely depends on their synthesis routes, and dictates the strategies used for functionalization. Two main strategies can be found in the literature: the design of core-shell nanosystems, or embedding nanoparticles in organic materials. Emerging tendencies such as the use of clusters or alternative coating materials are also described. To present both hydrophilic and lipophilic nanosystems, we chose the doxorubicin anticancer agent as an example, as the molecule presents an affinity for both types of materials. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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