Organophosphate Urinary Metabolite Levels during Pregnancy, Delivery and Postpartum in Women Living in Agricultural Areas in Thailand
| Autor: | Punnee Srasom, Kitsiluck Wilaiwan, Prapin Tharnpoophasiam, Pornpimol Kongtip, Susan Woskie, Noppanun Nankongnab, Akkarat Phamonphon |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Pregnancy Trimester Third Urinary system Metabolite Intelligence Physiology Rural Health Urine Nervous System Gas Chromatography-Mass Spectrometry Article Young Adult chemistry.chemical_compound Child Development Pregnancy parasitic diseases Humans Medicine Longitudinal Studies Pesticides Child business.industry Postpartum Period Organophosphate Public Health Environmental and Occupational Health Agriculture Environmental Exposure Environmental exposure Pesticide Thailand medicine.disease Organophosphates chemistry Prenatal Exposure Delayed Effects Female business Postpartum period |
| Zdroj: | Journal of Occupational Health. 55:367-375 |
| ISSN: | 1348-9585 1341-9145 |
| DOI: | 10.1539/joh.13-0040-oa |
| Popis: | OBJECTIVE Prenatal exposure to organophosphate pesticides can lead to developmental neurotoxicity. A longitudinal birth cohort was established to investigate pesticide exposures from different agricultural activities. Maternal urinary organophosphate metabolites were measured at 28 weeks of pregnancy (n=86), delivery (n=67) and 2 months postpartum (n=51). METHOD Subjects were interviewed with questionnaires about work, home and behavioral factors potentially associated with pesticide exposures, and spot urine samples were also collected. The urine samples were analyzed for dimethyl phosphate (DMP), diethyl phosphate (DEP), diethyl thiophosphate (DETP) and diethyl dithiophosphate (DEDTP), using gas chromatography-mass spectrometry. RESULTS The urinary DMP and dialkyl phosphate (DAP) concentrations at 28 weeks of pregnancy and delivery were not significantly different, but the DMP and DAP concentrations at 28 weeks of pregnancy and DAP concentrations at delivery were significantly different (p |
| Databáze: | OpenAIRE |
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