Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)

Autor:	Yuki Hitora, Hikaru Kato, Mika Nagaki, Momona Sebe, Keisuke Eguchi, Robert M. Williams, Sachiko Tsukamoto, Ippei Kagiyama, Jens Christian Frisvad
Rok vydání:	2019
Předmět:	Proteasome Endopeptidase Complex Magnetic Resonance Spectroscopy Aspergillus taichungensis Pharmaceutical Science Osteoclasts 01 natural sciences Norditerpenes Analytical Chemistry HeLa Anti-Infective Agents Drug Discovery Humans Pharmacology Antibiotics Antineoplastic biology Molecular Structure 010405 organic chemistry Chemistry Anticholesteremic Agents Organic Chemistry RANK Ligand Nuclear magnetic resonance spectroscopy biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry Aspergillus Complementary and alternative medicine Molecular Medicine Diterpenes Nuclear chemistry HeLa Cells
Zdroj:	Journal of natural products. 82(5)
ISSN:	1520-6025
Popis:	Four new norditerpenes, taichunins A-D (1-4), were isolated from the fungus Aspergillus taichungensis (IBT 19404). Compound 1 has a new carbon framework. The absolute configurations were determined by the calculated ECD spectral method. Compound 1 was cytotoxic against HeLa cells with an IC50 value of 4.5 μM, whereas 2-4 were nontoxic at 50 μM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d361108a20949a6e060afccef74f9f https://pubmed.ncbi.nlm.nih.gov/30995043 Zobrazit plný text záznamu