Effect of bovine lactoferrin on prevention of late-onset sepsis in infants <1500 g: a pooled analysis of individual patient data from two randomized controlled trials

Autor:	Jaime Zegarra, Anne Castañeda, Theresa J. Ochoa, Jan Jacobs, Karina Mendoza, Sicilia Bellomo, Cesar Carcamo, Luis Cam, Veerle Cossey, Sebastian Loli, Miguel Campos
Rok vydání:	2021
Předmět:	Risk perception Pilot Projects Bovine lactoferrin Biochemistry law.invention sepsis 0302 clinical medicine Randomized controlled trial Dairies law Mammals septicémie 030219 obstetrics & reproductive medicine biology Late onset sepsis Treatment group Lactoferrin Inclusion and exclusions néonatal lactoferrine lactoferrin Pooled analysis Regression analysis Protective effects Infant Premature medicine.medical_specialty purl.org/pe-repo/ocde/ford#1.06.03 [https] Birth weight neonatal Sepsis 03 medical and health sciences 030225 pediatrics Internal medicine First episodes medicine Animals Humans purl.org/pe-repo/ocde/ford#1.06.01 [https] Molecular Biology Milk Human business.industry Infant Newborn Preventative effect essai contrôlé randomisé Cell Biology Patient data medicine.disease Hospital data processing biology.protein Individual patient data Cattle business
Zdroj:	Biochemistry and Cell Biology. 99:14-19
ISSN:	1208-6002 0829-8211
Popis:	We previously conducted two randomized controlled trials with bovine lactoferrin (bLF) for the prevention of late-onset sepsis (LOS) in infants with a birth weight –1·day–1], and used the same control (maltodextrin). We fitted multivariate Cox regression models to estimate the effect of bLF on the risk of development of the composite outcome, adjusting for covariates. We included 335 neonates with a mean birth weight of 1162 ± 244 g; 27.5% were
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7bf96330b1c28a90a06fcc06318b46b https://doi.org/10.1139/bcb-2020-0046 Zobrazit plný text záznamu Plný text ve formátu PDF