CT-planned accelerated hypofractionated radiotherapy in the radical treatment of non-small cell lung cancer
| Autor: | Jason F. Lester, Jon B Court, Nayyer Iqbal, Fergus Macbeth, Alison Brewster |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Cancer Research medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Risk Assessment Cohort Studies Radiotherapy High-Energy Carcinoma Non-Small-Cell Lung medicine Humans Stage (cooking) Lung cancer Aged Neoplasm Staging Proportional Hazards Models Retrospective Studies Aged 80 and over Radical treatment Analysis of Variance Lung business.industry Standard treatment Respiratory disease Dose-Response Relationship Radiation Radiotherapy Dosage Radical radiotherapy Middle Aged Prognosis medicine.disease Survival Analysis Surgery Radiation therapy Treatment Outcome medicine.anatomical_structure Oncology Female Dose Fractionation Radiation Radiology Tomography X-Ray Computed business |
| Zdroj: | Lung Cancer. 45:237-242 |
| ISSN: | 0169-5002 |
| DOI: | 10.1016/j.lungcan.2004.01.018 |
| Popis: | Surgery is the standard treatment for stage I, II and certain stage IIIA non-small cell lung cancers (NSCLC). A proportion of patients with technically operable NSCLC do not undergo surgery because of significant co-morbidity or refusal, and radical radiotherapy may cure some of these patients. Between April 1997 and March 2000, 135 consecutive patients with stage I-IIIB NSCLC were treated with CT-planned accelerated hypofractionated radical radiotherapy to a dose of 50–55 Gy in 15–20 fractions over 3–4 weeks at a single centre. The 2-year overall and cause-specific survival for all patients was 44.4% (95% CI=36.8, 53.7) and 47.8% (95% CI=39.9, 57.3) respectively. Overall median survival was 21 months (95% CI=18, 28). There were no reports of severe acute or late treatment-related toxicities. These results compare favourably with previously published studies on radical radiotherapy in NSCLC, suggesting this may be an effective and safe technique. |
| Databáze: | OpenAIRE |
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