The presence of small intestinal intraepithelial gamma/delta T-lymphocytes is inversely correlated with lymphoma development in refractory celiac disease
| Autor: | Chris J. J. Mulder, Marco W.J. Schreurs, Wieke H.M. Verbeek, B. Mary E. von Blomberg, Petra E.T. Scholten, D Joop Kuik |
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| Přispěvatelé: | Gastroenterology and hepatology, Pathology, Epidemiology and Data Science, CCA - Disease profiling |
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Pathology Lymphoma T cell T-Lymphocytes Gastroenterology Coeliac disease Antigen Refractory hemic and lymphatic diseases Internal medicine Immunopathology Intestine Small medicine Humans Intestinal Mucosa Aged Hepatology business.industry Gamma/Delta T-Lymphocyte nutritional and metabolic diseases Receptors Antigen T-Cell gamma-delta T lymphocyte Middle Aged medicine.disease Flow Cytometry digestive system diseases Celiac Disease medicine.anatomical_structure Female business |
| Zdroj: | American Journal of Gastroenterology, 103(12), 3152-3158. Springer Nature Verbeek, W H M, von Blomberg, B M E, Scholten, P E, Kuik, D J, Mulder, C J J & Schreurs, M W 2008, ' The presence of small intestinal intraepithelial gamma/delta T-lymphocytes is inversely correlated with lymphoma development in refractory celiac disease ', American Journal of Gastroenterology, vol. 103, no. 12, pp. 3152-3158 . https://doi.org/10.1111/j.1572-0241.2008.02213.x |
| ISSN: | 0002-9270 |
| DOI: | 10.1111/j.1572-0241.2008.02213.x |
| Popis: | In refractory celiac disease (RCD) type II, a phenotypically aberrant (CD7+ CD3- CD4/8-cytoplasmicCD3+) intraepithelial lymphocyte (IEL) population is present, and 50-60% of these patients develop enteropathy-associated T-cell lymphoma (EATL). TCRgammadelta+ IELs play an important role in mucosal repair, homeostasis, and tumor surveillance. Recently, human small intestinal TCRgammadelta+ IELs were shown to have regulatory potential in uncomplicated celiac disease (CD).In the present study, we investigated whether TCRgammadelta+ IELs are decreased in RCD II, providing a possible explanation for persisting mucosal damage and inflammation, and the emergence of aberrant T cells with clonal expansion to EATL.Multiparameter flow cytometric immunophenotyping was performed on IELs isolated from fresh small bowel biopsy specimens of relatively large distinct CD patient and control groups (N = 87).A significantly lower percentage of TCRgammadelta+ IELs was found in RCD II as compared to all other CD groups. In contrast, in uncomplicated CD patients significantly more TCRgammadelta+ IELs were found than in controls. Overall, there is a clear negative relation between TCRgammadelta+ IELs and aberrant IELs. Interestingly, TCRgammadelta+ IELs increase again in RCD II after effective therapy.The observed negative relation between TCRgammadelta+ and aberrant IELs, along with their known regulatory capacity in uncomplicated CD, implies that TCRgammadelta+ IELs may play a crucial role in mucosal repair, regaining homeostasis and possibly even tumor surveillance. These cells may be important markers, in addition to the aberrant T cells, to differentiate between disease categories and to evaluate the effectiveness of therapeutic strategies. |
| Databáze: | OpenAIRE |
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