bcl-2 oncoprotein in surgically resected nonsmall cell lung cancer: Possibly favorable prognostic factor in association with low incidence of distant metastasis
| Autor: | Hideoki Yokouchi, Osamu Doi, Ryuhei Tateishi, Ken Kodama, Masahiko Higashiyama, Shoji Nakamori |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Cell type Lung Neoplasms Cell medicine.disease_cause Metastasis Carcinoma Non-Small-Cell Lung medicine Humans Neoplasm Metastasis Survival rate Aged Aged 80 and over business.industry General Medicine Middle Aged Prognosis medicine.disease Immunohistochemistry respiratory tract diseases Survival Rate medicine.anatomical_structure Proto-Oncogene Proteins c-bcl-2 Oncology Tumor progression Carcinoma Squamous Cell Cancer research Female Surgery Carcinogenesis business Immunostaining |
| Zdroj: | Journal of Surgical Oncology. 64:48-54 |
| ISSN: | 1096-9098 0022-4790 |
| Popis: | BACKGROUND: The bcl-2 oncoprotein serves a regulatory function in permitting several cell types to die in an apoptotic process. Its overexpression probably plays a role in tumorigenesis and tumor development. The aim of this study was to determine the clinicopathological and prognostic significance of the bcl-2 oncoprotein in patients with nonsmall cell lung cancer (NSCLC). METHODS: Immunostaining for bcl-2 oncoprotein was performed on 182 operable NSCLCs. RESULTS: Thirty-six patients (19.8%) showed a positive immunostaining for bcl-2 oncoprotein. Histologically, its incidence was higher in squamous cell carcinomas (29.6%). Its expression status was inversely correlated with tumor development-associated parameters such as tumor stage in NSCLCs, especially in squamous cell carcinomas, bcl-2 positive patients with NSCLCs, especially squamous cell carcinomas, showed better overall survival and disease-free survival (DFS). In a multivariate analysis, this oncoprotein status had prognostic value in DFS for NSCLCs and in overall survival for squamous cell carcinomas. The recurrence of bcl-2 positive NSCLCs was significantly uncommon in distant extrathoracic organs. CONCLUSIONS: The expression of bcl-2 oncoprotein in NSCLCs may be an early event of tumor development, especially in squamous cell carcinomas, and may be of importance in determining tumor progression and prognosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text