Exposure to bisphenol analogues interrupts growth, proliferation, and fatty acid compositions of protozoa Tetrahymena thermophila
| Autor: | Jing Li, Hexia Chen, Yichao Huang, Sen Hou, Jie Wang, Zhiqiang Sun, Da Chen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
endocrine system
Bisphenol A Environmental Engineering Bisphenol Health Toxicology and Mutagenesis Population 0211 other engineering and technologies 02 engineering and technology 010501 environmental sciences 01 natural sciences Tetrahymena thermophila chemistry.chemical_compound Phenols Biosynthesis Environmental Chemistry Benzhydryl Compounds education Waste Management and Disposal Cell Proliferation 0105 earth and related environmental sciences chemistry.chemical_classification 021110 strategic defence & security studies education.field_of_study biology Fatty acid metabolism urogenital system Fatty Acids Tetrahymena Fatty acid biology.organism_classification Pollution Enzyme chemistry Biochemistry hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Hazardous Materials. 395:122643 |
| ISSN: | 0304-3894 |
| Popis: | A number of bisphenol A (BPA) analogues are increasingly used as its industrial alternatives. However, their effects on aquatic organisms at both individual and population levels have not been well understood. In this study, effects of five bisphenol analogues (i.e., BPA, BPAF, BPB, BPE and BPS) were investigated by using the unicellular eukaryote Tetrahymena thermophila as a model organism. All of them inhibited individual growth and population proliferation at a concentration of 2.6 μM or 13.0 μM during the 60-h exposure period, with the population suppression capacify ranked as: BPB > BPA ≈ BPAF > BPE > BPS. These analogues also exhibited chemical-specific disruption of fatty acid profiles in single-cell eukaryotes and the transcriptional levels of enzymes involved in fatty acid metabolism/biosynthesis. For example, exposure to BPA and BPE significantly increased the ratio of saturated fatty acids to unsaturated fatty acids, contrary to the desaturation effects exhibited by BPAF and BPB. Overall, our results clearly indicated that these bisphenol analogues could pose chemical-specific effects on low-trophic level aquatic organisms, particularly disruption of endogenous metabolic balances. Selected analogues (i.e., BPB and BPAF) could result in effects similar to or even greater than that of BPA. |
| Databáze: | OpenAIRE |
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