| Autor: |
Analía Rearte, Carla Vizzotti, Adriana Haidar, Raúl Ruvinsky, Maria Eugenia Cafure, Sofia Fossati, Cristina Cortiana, Federico Avaro, Hugo Cozzani, Mabel Regueira, Omar Veliz, Luis Fernando Gentile, Maria Elisa Tito, Judit Kupervaser |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Open Forum Infectious Diseases |
| ISSN: |
2328-8957 |
| Popis: |
Background In January 2012, Argentine introduced PCV-13 to the National Immunization Program. We performed an epidemiological study in order to describe consolidated pneumonia and pneumococcal disease incidence following PCV-13 routine vaccination. Methods Between April2014-March2016, a population-based surveillance study was carried out in Concordia. Clinical data, vaccination status and digital chest X-rays were recorded from children < 5 years old with pneumonia and pleural effusion. A pediatrician and a radiologist interpreted the images independently. A second reference radiologist arbitrated when discordances occurred. Bacterial etiology was investigated in blood and/or in pleural fluid. Probably bacterial pneumonia (PBP) was determined following WHO protocol. Results were compared with previous data (2002–2005) from the pre-PCV-13 vaccination era. Variables associated to consolidated pneumonia were evaluated by multivariate analysis using logistic regression Results 330 patients under 5 years old with pneumonia were assisted during the study period. Of these, 92 (27.9%-IC95% 23.2–33.1) were classified as PBP. Annual incidence rate, in pre and post vaccination period and impact of vaccination are described in table 1. Incidence of pneumococcal disease could not be estimated as pneumococcal isolation was negative in all cases. Multivariate analysis of post-PCV-13 vaccination era showed that incidence of consolidated pneumonia was significantly higher in hospitalized toddlers than outpatients OR: 2,97 (1,65–5,38). Table 1: PBP incidence (*100.000) by study period. Vaccination impact Final Classification Pre-vacccination period Post vaccination period Impact of vaccination N Population Incidence n Population Incidence Incidence Rate ratio (IC95%) Decrease P value Consolidated pneumonia 387 18.053 714,6 86 15.493 283.9 2.5 (1.8–3.6) 60.2% |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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