Anti-Tumor Effects of Vitamin B2, B6 and B9 in Promonocytic Lymphoma Cells
| Autor: | Kathleen Mikkelsen, Monica D. Prakash, Lily Stojanovska, Nyanbol Kuol, Kulmira Nurgali, Vasso Apostolopoulos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male vitamin B2 Lymphoma U937 cell line vitamin B9 Inflammation Apoptosis folate vitamin B6 Catalysis Article lcsh:Chemistry Inorganic Chemistry Immune system Folic Acid Cell Movement Cell Line Tumor Medicine Anticarcinogenic Agents Humans Physical and Theoretical Chemistry riboflavin lcsh:QH301-705.5 Molecular Biology Spectroscopy pyridoxine Cell Proliferation business.industry Cell growth Organic Chemistry pro-monocytes General Medicine vitamin B complex Pyridoxine medicine.disease Vitamin B 6 Computer Science Applications lcsh:Biology (General) lcsh:QD1-999 Cell culture Cancer cell Cancer research medicine.symptom business medicine.drug |
| Zdroj: | International Journal of Molecular Sciences Volume 20 Issue 15 International Journal of Molecular Sciences, Vol 20, Iss 15, p 3763 (2019) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms20153763 |
| Popis: | Chronic inflammation can lead to tumour initiation and progression. Vitamin B complex has the ability to regulate the immune response and, therefore, inflammation but many of the mechanistic and molecular processes involved in this regulation are still not fully understood. This study sought to determine some of these processes by studying the effects of vitamin B2 (riboflavin) B6 (pyridoxine) and B9 (folic acid) on un-differentiated pro-monocytic lymphoma cells in regard to their ability to alter the proliferation, migration, apoptosis, cytokines and expression levels of programmed death ligand 1. We show that vitamin B2, B6 and B9, on pro-monocytic lymphoma cells exerted an anti-tumorigenic effect. This data could form the basis for future studies in using vitamin B supplementation to reduce cancer cell growth in vivo. |
| Databáze: | OpenAIRE |
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