| Autor: |
Joseph A. Califano, Christine H. Chung, Patrick Hennessey, William H. Westra, Rajni Sharma, Justin Bishop, Gary Latham, Alex Adai, Will Darden, Ashish Choudhary, Tiffany Sanford, Kalyan Buddavarapu, Jeffery Houghton, David Sidransky, Elana Fertig, Sun Ahn, Ryan Li, Jason Howard, Nishant Agrawal, Myriam Loyo, Yan Liu, Demetri Arnaoutakis, Elizabeth Mambo, Michael F. Ochs, Daria A. Gaykalova, Wenyue Sun |
| Rok vydání: |
2023 |
| DOI: |
10.1158/0008-5472.22401659 |
| Popis: |
PDF file - 82K, Growth effects of NOTCH1 siRNA inhibition in HNSCC cells with wildtype NOTCH1 status. NOTCH1 was downregulated in UPCI-SCC090 (090, top, NOTCH1 wt) and SCC61 (bottom, NOTCH1 wt) by siRNA as described in methods. The effect of NOTCH1 downregulation on cell proliferation for these two cell lines is shown in the middle. The effect of siNOTCH1 on NOTCH1 expression (left) or expression of its targets (HES1 and HEY1, right) is also shown. The mRNA expression levels were calculated relative to GAPDH and were normalized to 1 in the control experiments with scrambled siRNA sequences. Experiments were performed in pentaplicates, mean plus-minus SEM were shown. *, p-value < 0.05. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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