Fast degrading elastomer stented fascia remodels into tough and vascularized construct for tracheal regeneration
| Autor: | Wanli Chen, Sansan Jia, Xuzheng Liu, Siqian Zhang, Wei Wu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Glycerol
Materials science Polymers Polyesters Neovascularization Physiologic Bioengineering 02 engineering and technology 010402 general chemistry Elastomer 01 natural sciences Regenerative medicine Epithelium Biomaterials Blood Vessel Prosthesis Implantation chemistry.chemical_compound medicine Animals Regeneration Fascia Tissue Scaffolds biology Regeneration (biology) Decanoates technology industry and agriculture musculoskeletal system 021001 nanoscience & nanotechnology Electrospinning Blood Vessel Prosthesis 0104 chemical sciences Trachea medicine.anatomical_structure Elastomers chemistry Mechanics of Materials Polycaprolactone biology.protein Stents Rabbits Epithelium regeneration 0210 nano-technology Porosity Elastin Biomedical engineering |
| Zdroj: | Materials Science and Engineering: C. 101:1-14 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2019.02.108 |
| Popis: | Tracheal reconstruction remains a major surgical challenge, mainly owing to the scarce of resilient hollow grafts with identifiable vascular pedicle in humans. In this study, we developed a three-layer, elastomeric, trachea-like composite made of poly glycerol sebacate (PGS) and polycaprolactone (PCL), which presented appropriate resilient property, timely degradation and interconnected pores. C shape PCL rings fabricated with selective laser sintering (SLS) techniques are regularly positioned around porous PGS tubes and fixed by PCL electrospinning sheath. Such an elastomeric composite underwent host remodeling including rapid vascularization and tissue infiltration after fascia wrapping. With degrading of PGS, C rings well incorporated into growing fascia and lead to the formation of pedicled tracheal grafts, which attributes to the strong and resilient properties of generated hollow grafts thus enabled orthotopic transplantation in segmental tracheal defect. Progressive remodeling on such vascularized and mechanically stable grafts resulted in epithelium regeneration on luminal side as well as production of adequate amount of collagen and elastin, which warrantees the air passage during breathing. Future study employing large animal models more representative of human tracheal regeneration is warranted before clinical translation. Using fast degrading PGS combined with PCL rings represents a philosophical shift from the prevailing focus on tough grafts in airway reconstruction and may impact regenerative medicine in general. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect