Basal ganglia structures differentially contribute to verbal fluency: Evidence from Human Immunodeficiency Virus (HIV)-infected adults
| Autor: | Vanessa Streiff, Stella E. Panos, Suzie El-Saden, Jessica M. Foley, Susan Y. Bookheimer, Matthew Wright, Scott Goodwin, Mark L. Ettenhofer, April D. Thames, Amir Ramezani, Charles H. Hinkin |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Cognitive Neuroscience Caudate nucleus Human immunodeficiency virus (HIV) HIV Infections Experimental and Cognitive Psychology Neuropsychological Tests Audiology medicine.disease_cause behavioral disciplines and activities Article Basal Ganglia Developmental psychology Executive Function Behavioral Neuroscience Nonverbal communication Fluency Phonetics Basal ganglia medicine Humans Speech Verbal fluency test Verbal Behavior Putamen Neuropsychology Middle Aged Magnetic Resonance Imaging Semantics Female Caudate Nucleus Psychology |
| Zdroj: | Neuropsychologia. 50:390-395 |
| ISSN: | 0028-3932 |
| Popis: | Background The basal ganglia (BG) are involved in executive language functions (i.e., verbal fluency) through their connections with cortical structures. The caudate and putamen receive separate inputs from prefrontal and premotor cortices, and may differentially contribute to verbal fluency performance. We examined BG integrity in relation to lexico-semantic verbal fluency performance among older HIV infected adults. Method 20 older (50+ years) HIV+ adults underwent MRI and were administered measures of semantic and phonemic fluency. BG (caudate, putamen) regions of interest were extracted. Results Performance on phonemic word generation significantly predicted caudate volume, whereas performance on phonemic switching predicted putamen volume. Conclusions These findings suggest a double dissociation of BG involvement in verbal fluency tasks with the caudate subserving word generation and the putamen associated with switching. As such, verbal fluency tasks appear to be selective to BG function. |
| Databáze: | OpenAIRE |
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