Improvement of Skin Permeation of Caffeine, a Hydrophilic Drug, by the Application of Water Droplets Provided by a Novel Humidifier Device
| Autor: | Hiroaki Todo, Yuya Hasegawa, Kenji Sugibayashi, Akie Okada, Shoko Itakura |
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| Rok vydání: | 2021 |
| Předmět: |
Skin Absorption
Rats Hairless topical drug formulation Administration Cutaneous enhanced skin permeation Humidifiers Permeability Styrene hydrophilic drug chemistry.chemical_compound cosmetic formulation PEDOT:PSS Caffeine Drug Discovery Copolymer Stratum corneum medicine Animals Particle Size skin hydration Skin integumentary system Air humidifier Temperature Water Humidity General Chemistry General Medicine Permeation eye diseases Rats Sulfonate medicine.anatomical_structure chemistry Chemical engineering Emulsion Hydrophobic and Hydrophilic Interactions |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 69:727-733 |
| ISSN: | 1347-5223 0009-2363 |
| DOI: | 10.1248/cpb.c21-00110 |
| Popis: | Recently, a novel humidifier that sprays water fine droplets equipped with a copolymer, poly(3,4-ethylene dioxythiophene)-poly(styrene sulfonate) (PEDOT/PSS) was developed. PEDOT/PSS in the humidifier absorbs water from the environment and releases fine water droplets by heating. In the present study, the effect of hydration on the skin barrier, stratum corneum, was first determined by the application of fine water droplets using the humidifier. The skin-penetration enhancement effect of a model hydrophilic drug, caffeine, was also investigated using the humidifier and compared with a conventional water-evaporative humidifier. More prolonged skin hydration effect was observed after application of the fine water droplet release humidifier using PEDOT/PSS than that using a conventional humidifier. In addition, markedly higher skin permeation of caffeine was observed in both infinite and finite dose conditions. Furthermore, higher skin permeation of caffeine from oil/water emulsion containing caffeine was observed in finite dose conditions by pretreatment with the humidifier using PEDOT/PSS. This device can provide water droplets without replenishing water, so it is more convenient for enhancing the skin permeation of chemical compounds from topical drugs and cosmetic formulations. |
| Databáze: | OpenAIRE |
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