Interaction of beta-lactam antibiotics on bilirubin-albumin complex: comparison by three methods, total bilirubin, unbound bilirubin and erythrocyte-bound bilirubin
| Autor: | Veronique Gonard, Christiane Dalmasso, Jean-Marc Gulian |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Erythrocytes
medicine.drug_class Bilirubin Cefotetan Cephalosporin Antibiotics beta-Lactams chemistry.chemical_compound Drug Discovery medicine Humans Pharmacology (medical) Drug Interactions Serum Albumin Pharmacology Chromatography Chemistry Albumin General Medicine Anti-Bacterial Agents Penicillin Cefoperazone Infectious Diseases Oncology Ceftriaxone medicine.drug Protein Binding |
| Zdroj: | Chemotherapy. 36(2) |
| ISSN: | 0009-3157 |
| Popis: | The effects of 'third-generation' cephalosporins and penicillin analogues on the concentrations of total unconjugated bilirubin, unbound bilirubin and erythrocyte-bound bilirubin were determined in blood samples. This study was performed, in vitro, at two bilirubin/albumin molar ratios and at various concentrations of antibiotics. The most effective displacers, considering the three methods, were antibiotics tightly bound to albumin: ceftriaxone and cefotetan. Cefoperazone, which is bound to albumin as tightly as these two antibiotics, caused no significant increase in unbound bilirubin but should be considered as a displacer drug on the basis of the variations of erythrocyte-bound bilirubin and total bilirubin. We suggest that drug interaction on bilirubin-albumin binding be investigated by several methods. |
| Databáze: | OpenAIRE |
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