The biochemical effects of lime concentrate ‘Aporo’ and Mucuna pruriens seeds extract on Alloxan-induced diabetic rats
| Autor: | Yvonne O. Akujobi, Adeolu A. Taiwo, Damilola G. Oyewale, Oluyomi Stephen Adeyemi, Jenifer A. Okosun, David Adeiza Otohinoyi, S.O. Owa, Omodele Ibraheem, Theresa I. Edewor-Ikupoyi |
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| Rok vydání: | 2016 |
| Předmět: |
Mucuna
medicine.medical_treatment 030231 tropical medicine Intraperitoneal injection Decoction Glibenclamide 03 medical and health sciences chemistry.chemical_compound مضاد للأكسدة Diabetes mellitus 0302 clinical medicine Oral administration Alloxan medicine 030212 general & internal medicine Traditional medicine biology Chemistry Antidyslipidaemic مضاد لعدم اتزان الدهون في الدم General Medicine medicine.disease biology.organism_classification داء السكري Glucose مضاد للسكري Antidiabetic Antioxidant الجلوكوز Mucuna pruriens medicine.drug |
| Zdroj: | Journal of Taibah University Medical Sciences. 11(3):260-267 |
| ISSN: | 1658-3612 |
| DOI: | 10.1016/j.jtumed.2016.02.004 |
| Popis: | Objectives This study evaluated the biochemical properties of a local lime concentrate preparation called Aporo and an ethanolic extract of seeds of Mucuna pruriens . Methods Six groups of male Wistar rats, each containing five rats, were selected. Diabetes was induced in all rats, except the negative control group, by a single intraperitoneal injection of 150 mg/kg Alloxan. The induced rats, apart from the diabetic control group, were treated by daily oral administration of 5 mg/kg Glibenclamide, 100 mg/kg of Aporo decoction, an ethanolic extract of M. pruriens seed, and a combination of both in equal doses. Results After 15 days of treatment, the blood glucose level of rats in the positive control group was found to be significantly lower than that of the other rats. However, Aporo extract exhibited a significantly higher ability to reduce blood glucose than the standard hypoglycaemic drug Glibenclamide. Aporo also increased high-density lipoprotein (HDL) levels and decreased triglyceride levels. The results showed that Aporo exhibited significant antioxidant, antidiabetic and antidyslipidaemic properties when used alone rather than in combination with Mucuna seed extracts. Conclusion This study endorses the folk use of Aporo in the treatment of diabetes. However, further experimental studies are required to complement the results of the current study. |
| Databáze: | OpenAIRE |
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