Study of Irisin Hormone Level in Type 2 Diabetic Patients and Patients with Diabetic Nephropathy
| Autor: | Meram M. Bekhet, Salah Shelbaya, Merhan Samy Nasr, Magdy Abbas, Manal Mohamed Abu Shady, Yasmine Abd-Al Mageed |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Blood Glucose Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Down-Regulation Serum Albumin Human Type 2 diabetes Diabetic nephropathy 03 medical and health sciences chemistry.chemical_compound Endocrinology Internal medicine Diabetes mellitus Medicine Humans Diabetic Nephropathies Glycated Hemoglobin Kidney Creatinine business.industry Albumin Middle Aged medicine.disease Fibronectins 030104 developmental biology medicine.anatomical_structure Blood pressure chemistry Diabetes Mellitus Type 2 Case-Control Studies Multivariate Analysis Female business Biomarkers Kidney disease |
| Zdroj: | Current diabetes reviews. 14(5) |
| ISSN: | 1875-6417 |
| Popis: | BACKGROUND Type 2 diabetic patients with diabetic nephropathy are associated with multifactorial abnormal energy metabolism. Irisin has been recently introduced as a hormone that is exercise-induced and is secreted by skeletal muscles. It is hypothesized that patients with chronic kidney disease usually have abnormal irisin levels. AIM We aimed to study the level of Irisin hormone in patients with type 2 diabetes and to document that it is related to diabetic nephropathy. METHODS The current study included 60 subjects with type 2 diabetes and 30 healthy subjects as a control group. Diabetic subjects were divided into 30 without diabetic complications and 30 with diabetic nephropathy (DN). Serum Irisin levels, fasting blood glucose (FBG), 2hours plasma glucose (2hPG), hemoglobin A1c (HbA1c), kidney functions including serum creatinine and albumin/ creatinine ratio were assessed. RESULTS There was a statistically significant decrease in Irisin levels in diabetic patients compared to controls (34.46 ± 15.28 ng/ml vs. 152.600 ± 39.581 ng/ml, p |
| Databáze: | OpenAIRE |
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