Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life
| Autor: | Dongya Zhang, Yan Xia, Dorota Ewa Kotowska, Jianfeng Zhang, Valentina Tremaroli, Xun Xu, Jovanna Dahlgren, Jun Wang, Ye Yin, Yangqing Peng, Josefine Roswall, Huijue Jia, Ying Shiuan Lee, Karsten Kristiansen, Lise Madsen, Camilla Colding, Fredrik Bäckhed, Yin Li, Petia Kovatcheva-Datchary, Junhua Li, Muhammad Tanweer Khan, Liang Xiao, Qiang Feng, Stefan Bergman, Jumana Y. Al-Aama, Huanzi Zhong, Hailiang Xie |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Cancer Research Molecular Sequence Data Physiology First year of life Biology Gut flora Bioinformatics digestive system Microbiology Feces Human gut Immunology and Microbiology(all) Virology Humans Microbiome Molecular Biology Sweden Microbiota Gastrointestinal Microbiome Infant Newborn Infant Sequence Analysis DNA Delivery Obstetric biology.organism_classification Gastrointestinal Tract Breast Feeding Metagenomics Parasitology Breast feeding |
| Zdroj: | Cell Host & Microbe. 17:690-703 |
| ISSN: | 1931-3128 |
| DOI: | 10.1016/j.chom.2015.04.004 |
| Popis: | SummaryThe gut microbiota is central to human health, but its establishment in early life has not been quantitatively and functionally examined. Applying metagenomic analysis on fecal samples from a large cohort of Swedish infants and their mothers, we characterized the gut microbiome during the first year of life and assessed the impact of mode of delivery and feeding on its establishment. In contrast to vaginally delivered infants, the gut microbiota of infants delivered by C-section showed significantly less resemblance to their mothers. Nutrition had a major impact on early microbiota composition and function, with cessation of breast-feeding, rather than introduction of solid food, being required for maturation into an adult-like microbiota. Microbiota composition and ecological network had distinctive features at each sampled stage, in accordance with functional maturation of the microbiome. Our findings establish a framework for understanding the interplay between the gut microbiome and the human body in early life. |
| Databáze: | OpenAIRE |
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